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Abdominal Radiology

, Volume 43, Issue 11, pp 3117–3124 | Cite as

3T multiparametric MR imaging, PIRADSv2-based detection of index prostate cancer lesions in the transition zone and the peripheral zone using whole mount histopathology as reference standard

  • Nazanin Hajarol Asvadi
  • Sohrab Afshari Mirak
  • Amirhossein Mohammadian Bajgiran
  • Pooria Khoshnoodi
  • Pornphan Wibulpolprasert
  • Daniel Margolis
  • Anthony Sisk
  • Robert E. Reiter
  • Steven S. Raman
Article

Abstract

Purpose

To evaluate 3T mpMRI characteristics of transition zone and peripheral zone index prostate cancer lesions stratified by Gleason Score and PI-RADSv2 with whole mount histopathology correlation.

Methods

An institution review board-approved, HIPAA-compliant single-arm observational study of 425 consecutive men with 3T mpMRI prior to radical prostatectomy from December 2009 to October 2016 was performed. A genitourinary radiologist and a genitourinary pathologist matched all lesions detected on whole mount histopathology with lesions concordant for size and location on 3T mpMRI. Differences in clinical, MRI parameters, and histopathology between transition zone and peripheral zone were determined and analyzed with χ2 and Mann–Whitney U test. AUC was measured.

Results

3T mpMRI detected 248/323 (76.7%) index lesions in peripheral zone and 75/323 (23.2%) in transition zone. Transition zone prostate cancer had higher median prostate-specific antigen (p = 0.001), larger tumor on 3T mpMRI (p = 0.001), lower proportions of PI-RADSv2 category 4 and 5 (p < 0.001), and lower pathological stage (p = 0.055) compared to peripheral zone prostate cancer. No significant differences were detected in prostate-specific antigen density, preoperative biopsy, and pathology Gleason Scores. After adjusting for significant variables from univariate analysis including prostate volume, tumor volume, prostate-specific antigen, PI-RADSv2 category, AUC for predicting clinically significant tumor in transition zone and peripheral zone were 0.80 and 0.72, respectively (p = 0.36).

Conclusions

The diagnostic performance of PI-RADSv2 for clinically significant transition and peripheral zone prostate cancer was similar. However, there was a lower portion of PI-RADSv2 4 and 5 lesions in transition zone compared to peripheral zone.

Keywords

Prostate cancer Multiparametric magnetic resonance imaging PI-RADSv2 Gleason score 

Notes

Acknowledgements

We are grateful to Mark DeMars, William Hsu, Wenchao Tao, and Cleo Maehara who support our research. Statistical analyses for this research were supported by NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant Number UL1TR001881. We are also thankful to Tristan R. Grogan for his statistical analyses support.

Compliance with ethical standards

Financial disclosure

The study was supported in part by the department of Radiology and Pathology Integrated Diagnostics (IDx) program and specialized program of research excellence (SPORE) of PCa.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was performed in accordance with the 1996 Health Information Portability and Accountability Act (HIPAA) and under waiver of informed consent by the institutional review board (IRB).

Informed consent

For this type of study formal consent is not required.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Nazanin Hajarol Asvadi
    • 1
  • Sohrab Afshari Mirak
    • 1
  • Amirhossein Mohammadian Bajgiran
    • 1
  • Pooria Khoshnoodi
    • 1
  • Pornphan Wibulpolprasert
    • 2
  • Daniel Margolis
    • 3
  • Anthony Sisk
    • 4
  • Robert E. Reiter
    • 5
  • Steven S. Raman
    • 1
    • 5
  1. 1.Department of Radiological SciencesDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of RadiologyRamathibodi HospitalBangkokThailand
  3. 3.Department of RadiologyWeill Cornell Imaging, NewYork-PresbyterianNew YorkUSA
  4. 4.Department of PathologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  5. 5.Department of UrologyDavid Geffen School of Medicine at UCLALos AngelesUSA

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