Abdominal Radiology

, Volume 44, Issue 5, pp 1686–1702 | Cite as

Mucinous appendiceal neoplasms: classification, imaging, and HIPEC

  • David J. Bartlett
  • Paul G. ThackerJr.
  • Travis E. Grotz
  • Rondell P. Graham
  • Joel G. Fletcher
  • Wendaline M. VanBuren
  • Veena R. Iyer
  • Jeff L. Fidler
  • Christine O. Menias
  • Nabil Wasif
  • Shannon P. SheedyEmail author
Review Paper


Recent advances, specifically cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), offer advantages compared to the traditional therapeutic approach of systemic chemotherapy in the treatment of peritoneal carcinomatosis from mucinous appendiceal neoplasms (MAN). This review provides an up-to-date, comprehensive summary of the histologic classification of MAN, reviews common imaging findings of mucoceles and pseudomyxoma peritonei, and describes the radiologist’s role in the multidisciplinary care team in quantifying disease and in helping select patients for definitive surgery.


Mucinous appendiceal neoplasm, MAN Hyperthermic intraperitoneal chemotherapy, HIPEC Cytoreductive surgery Pseudomyxoma peritonei, PMP 



The authors acknowledge the assistance of Sonia Watson, PhD, in preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Supplementary material

261_2018_1888_MOESM1_ESM.pdf (65 kb)
Supplementary material 1 (PDF 64 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of RadiologyMayo ClinicRochesterUSA
  2. 2.Department of Hepatobiliary and Pancreatic SurgeryMayo ClinicRochesterUSA
  3. 3.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  4. 4.Department of RadiologyMayo ClinicScottsdaleUSA
  5. 5.Department of General SurgeryMayo ClinicScottsdaleUSA

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