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Abdominal Radiology

, Volume 43, Issue 7, pp 1567–1574 | Cite as

Reproducible imaging features of biologically aggressive gastrointestinal stromal tumors of the small bowel

  • Francisco J. Maldonado
  • Shannon P. Sheedy
  • Veena R. Iyer
  • Stephanie L. Hansel
  • David H. Bruining
  • Cynthia H. McCollough
  • William S. Harmsen
  • John M. Barlow
  • Joel G. Fletcher
Article
  • 111 Downloads

Abstract

Purpose

To identify reproducible CT imaging features of small bowel gastrointestinal stromal tumors (GIST) that are associated with biologic aggressiveness.

Methods

Patients with histologically proven small bowel GISTs and CT enterography or abdominopelvic CT were included. Biologic aggressiveness was established based on initial histologic grading (very low risk to malignant), with “malignant” assigned if recurrence or metastases developed subsequently. CT exams were independently evaluated by three gastrointestinal radiologists for tumor size, growth pattern, enhancement, tumor borders, necrosis, calcification, ulceration, multiplicity, internal air or enteric contrast, nodal metastasis, liver metastasis, peritoneal metastasis, ascites, and draining vein size. Inter-observer variability and imaging features associated with high-grade and malignant small bowel GISTs were determined.

Results

Of 78 patients with small bowel GISTs, 10/78 (13%) were high grade and 18/78 (23%) were malignant. There was moderate to substantial inter-observer agreement (Kappa > 0.4) for all findings except tumor border, ulceration, and nodal metastases. Tumor size, irregular or invasive tumor border, necrosis, liver metastasis, ascites, and iso-enhancement were associated with high-grade/malignant small bowel GISTs (p < 0.04). Internal air or enteric contrast and peritoneal metastases additionally predicted malignant behavior (p < 0.03). When imaging features predicting malignant small bowel GISTs were absent and size was ≤ 3 cm, 0% (0/16), 5% (1/19), and 5% (1/17) of patients had high grade, and 0% (0/16, 0/19, and 0/17) had malignant tumors for the three readers, respectively.

Conclusion

Multiple, reproducibly identified, small bowel GIST imaging features suggest biologic aggressiveness. The absence of these imaging features may identify small tumors that can be followed in asymptomatic or high-risk patients.

Keywords

Small bowel Gastrointestinal stromal tumor Malignancy Small bowel bleeding 

Notes

Compliance with ethical standards

Funding

None.

Conflict of interest

Dr. McCollough receives grant support from Siemens Healthcare. No other authors declare a conflict of interest.

Research involving Human Participants and/or Animals & Informed Consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study. This article does not contain any animal studies.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Francisco J. Maldonado
    • 1
  • Shannon P. Sheedy
    • 1
  • Veena R. Iyer
    • 1
  • Stephanie L. Hansel
    • 1
  • David H. Bruining
    • 2
  • Cynthia H. McCollough
    • 1
  • William S. Harmsen
    • 3
  • John M. Barlow
    • 1
  • Joel G. Fletcher
    • 1
  1. 1.Department of RadiologyMayo ClinicRochesterUSA
  2. 2.Division of GastroenterologyMayo ClinicRochesterUSA
  3. 3.Department of Health Sciences ResearchMayo ClinicRochesterUSA

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