Abdominal Radiology

, Volume 42, Issue 12, pp 2909–2926 | Cite as

Collision and composite tumors; radiologic and pathologic correlation

  • Calvin T. Sung
  • Anup Shetty
  • Christine O. Menias
  • Roozbeh Houshyar
  • Shreya Chatterjee
  • Thomas K. Lee
  • Paul Tung
  • Mohammed Helmy
  • Chandana Lall
Invited article


The terms composite and collision tumors have been used interchangeably throughout radiological literature. Both composite and collision tumors involve two morphologically and immunohistochemically distinct neoplasms coexisting within a single organ. However, collision tumors lack the histological cellular intermingling seen in composite tumors. Composite tumors often arise from a common driver mutation that induces a divergent histology from a common neoplastic source while collision tumors may arise from coincidental neoplastic change. The purpose of this review is to provide an overview of abdominal composite and collision tumors by discussing hallmark radiographic and pathological presentations of rare hepatic, renal, and adrenal case studies. A better understanding of the presentation of each lesion is imperative for proper recognition, diagnosis, and management of these unique tumor presentations.


Biphenotypic Composite hepatocellular and cholangiocarcinoma Live collision Composite renal cell carcinoma Collision cholangiocarcinoma Renal collision Adrenal collision 


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Calvin T. Sung
    • 1
    • 2
  • Anup Shetty
    • 3
  • Christine O. Menias
    • 4
  • Roozbeh Houshyar
    • 1
  • Shreya Chatterjee
    • 1
  • Thomas K. Lee
    • 1
  • Paul Tung
    • 1
  • Mohammed Helmy
    • 1
  • Chandana Lall
    • 1
  1. 1.Department of Radiological Sciences, Irvine School of MedicineUniversity of CaliforniaOrangeUSA
  2. 2.School of MedicineUniversity of California RiversideRiversideUSA
  3. 3.Department of RadiologyWashington University School of Medicine in St. LouisSt. LouisUSA
  4. 4.Department of RadiologyMayo ClinicPhoenixUSA

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