A prospective comparison between auto-registration and manual registration of real-time ultrasound with MR images for percutaneous ablation or biopsy of hepatic lesions
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To compare the accuracy and required time for image fusion of real-time ultrasound (US) with pre-procedural magnetic resonance (MR) images between positioning auto-registration and manual registration for percutaneous radiofrequency ablation or biopsy of hepatic lesions.
This prospective study was approved by the institutional review board, and all patients gave written informed consent. Twenty-two patients (male/female, n = 18/n = 4; age, 61.0 ± 7.7 years) who were referred for planning US to assess the feasibility of radiofrequency ablation (n = 21) or biopsy (n = 1) for focal hepatic lesions were included. One experienced radiologist performed the two types of image fusion methods in each patient. The performance of auto-registration and manual registration was evaluated. The accuracy of the two methods, based on measuring registration error, and the time required for image fusion for both methods were recorded using in-house software and respectively compared using the Wilcoxon signed rank test.
Image fusion was successful in all patients. The registration error was not significantly different between the two methods (auto-registration: median, 3.75 mm; range, 1.0–15.8 mm vs. manual registration: median, 2.95 mm; range, 1.2–12.5 mm, p = 0.242). The time required for image fusion was significantly shorter with auto-registration than with manual registration (median, 28.5 s; range, 18–47 s, vs. median, 36.5 s; range, 14–105 s, p = 0.026).
Positioning auto-registration showed promising results compared with manual registration, with similar accuracy and even shorter registration time.
KeywordsFusion imaging Radiofrequency ablation Biopsy Liver Automatic registration
Compliance with ethical standards
This study was supported by Samsung Medison (Grant #PHO0132251).
Conflict of interest
Dong Kuk Shin, Sung Jin Choi, and Dalkwon Koh received support in the form of salaries from Samsung Medison. Min Woo Lee is a consultant for Samsung Medison. All other authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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