Abdominal Radiology

, Volume 42, Issue 6, pp 1659–1666 | Cite as

Magnetic resonance elastography in the assessment of hepatic fibrosis: a study comparing transient elastography and histological data in the same patients

  • Masafumi ToguchiEmail author
  • Masakatsu Tsurusaki
  • Norihisa Yada
  • Keitaro Sofue
  • Tomoko Hyodo
  • Minori Onoda
  • Isao Numoto
  • Mitsuru Matsuki
  • Izumi Imaoka
  • Masatoshi Kudo
  • Takamichi Murakami



To evaluate the quantitative measurement of liver stiffness (LS), compare the diagnostic performance of magnetic resonance elastography (MRE) and ultrasound-based transient elastography (TE), and evaluate two different MRE-based LS measurement methods.


Between October 2013 and January 2015, 116 consecutive patients with chronic liver disease underwent MRE to measure LS (kilopascals; kPa). Of the 116 patients, 51 patients underwent both TE and liver biopsy, and the interval between the liver biopsy and both the MRE and TE was less than 90 days. MRE-derived LS values were measured on the anterior segment of the right lobe (single small round regions of interest per slice; srROIs) and whole right lobe of the liver (free hand region of interest; fhROI), and these values were correlated with pathological fibrosis grades and diagnostic performance.


Pathological fibrosis stage was significantly correlated with srROIs (r = 0.87, p < 0.001), fhROI (r = 0.80, p < 0.001), and TE (r = 0.73, p < 0.001). For detection of significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis, the area under the curve (AUC) associated with the srROIs was largest, and there was a significant difference between srROIs and TE (0.93 vs. 0.82, p = 0.006), srROIs and fhROI (0.93 vs. 0.89, p = 0.04) for detection of ≥F2. For advanced fibrosis and cirrhosis detection, AUCs were not significant (0.92–0.96).


MRE and TE detected liver fibrosis with comparable accuracy. In particular, the srROIs method was effective for detecting of significant fibrosis.


MR elastography Transient elastography Liver fibrosis Fibrosis assessment Chronic liver disease 



We gratefully acknowledge the help of all radiological technologists working in the MRE division of our hospital.

Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Statement of informed consent was not applicable since the manuscript does not contain any patient data.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Masafumi Toguchi
    • 1
    Email author
  • Masakatsu Tsurusaki
    • 1
  • Norihisa Yada
    • 2
  • Keitaro Sofue
    • 3
  • Tomoko Hyodo
    • 1
  • Minori Onoda
    • 4
    • 5
  • Isao Numoto
    • 1
  • Mitsuru Matsuki
    • 1
  • Izumi Imaoka
    • 1
  • Masatoshi Kudo
    • 2
  • Takamichi Murakami
    • 1
  1. 1.Department of Radiology, Faculty of MedicineKindai UniversityOsaka-SayamaJapan
  2. 2.Department of Gastroenterology and Hepatology, Faculty of MedicineKindai UniversityOsaka-SayamaJapan
  3. 3.Department of RadiologyKobe University Graduate School of MedicineKobeJapan
  4. 4.Department of Radiological TechnologyKindai UniversityOsaka-SayamaJapan
  5. 5.Devision of Health Sciences, Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan

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