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Abdominal Radiology

, Volume 42, Issue 5, pp 1291–1297 | Cite as

Radiographic capsule-based system for non-cathartic colorectal cancer screening

  • Yoav Kimchy
  • Ronen Lifshitz
  • Shlomo Lewkowitz
  • Guiseppe Bertuccio
  • Nadir Arber
  • Nathan Gluck
  • Perry J. Pickhardt
Article

Abstract

Many patients are reluctant to undergo optical colonoscopy for colorectal cancer screening. The Check-Cap colon imaging system is a non-invasive test that comprises an ingestible imaging capsule that emits and detects ultra-low-dose radiation. The capsule generates a 3D reconstruction of the colonic lumen for detection of polyps and cancer. Preliminary preclinical and clinical testing has demonstrated safety and feasibility. Mean radiation dose is estimated at 0.04 mSv. In conclusion, we describe a novel capsule-based, patient-friendly colorectal test that holds potential for non-invasive screening.

Keywords

Colorectal cancer Colorectal polyps Screening Colon capsule 

Notes

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

Drs. Kimchy, Lifshitz, and Lewkowitz are employed by Check-Cap; Drs. Pickhardt and Arber are advisors to Check-Cap; Dr. Pickhardt is also co-founder of VirtuoCTC, and shareholder in Elucent, SHINE, and Cellectar Biosciences. The other authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Torre LA, Bray F, Siegel RL, et al. (2015) Global cancer statistics, 2012. CA 65:87–108PubMedGoogle Scholar
  2. 2.
    Levin B, Lieberman DA, McFarland B, et al. (2008) Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA 58:130–160PubMedGoogle Scholar
  3. 3.
    Pickhardt PJ (2016) Emerging stool-based and blood-based non-invasive DNA tests for colorectal cancer screening: the importance of cancer prevention in addition to cancer detection. Abdom RadiolGoogle Scholar
  4. 4.
    Pickhardt PJ (2015) CT colonography for population screening: ready for prime time? Dig Dis Sci 60:647–659CrossRefPubMedGoogle Scholar
  5. 5.
    Ranasinghe I, Parzynski CS, Searfoss R, et al. (2016) Differences in colonoscopy quality among facilities: development of a post-colonoscopy risk-standardized rate of unplanned hospital visits. Gastroenterology 150:103–113CrossRefPubMedGoogle Scholar
  6. 6.
    Rosenthal E (2013) The $2.7 trillion medical bill: colonoscopies explain why U.S. leads the world in health expenditures. The New York TimesGoogle Scholar
  7. 7.
    Bertuccio G, Caccia S, Macera D, et al. (2013) A mixed-signal ASIC for CdTe/CdZnTe detectors readout in battery powered capsule for colon 3D-imaging. IEEE Trans Nucl Sci 60:3872–3878CrossRefGoogle Scholar
  8. 8.
    Kimchy et al. Intra-lumen polyp detection, US patent 7,787,926Google Scholar
  9. 9.
    Baum et al. Estimation of distances and size of lesions in the colon with an imaging capsule, US patent 9,037,219Google Scholar
  10. 10.
    Gluck N, Shpak B, Brun R, et al. (2016) A novel prepless X-ray imaging capsule for colon cancer screening. Gut 65:371–373CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Yoav Kimchy
    • 1
  • Ronen Lifshitz
    • 1
  • Shlomo Lewkowitz
    • 1
  • Guiseppe Bertuccio
    • 2
  • Nadir Arber
    • 3
  • Nathan Gluck
    • 3
  • Perry J. Pickhardt
    • 4
  1. 1.Check-CapMount CarmelIsrael
  2. 2.Politecnico di MilanoMilanItaly
  3. 3.Tel Aviv Sourasky Medical Center; Tel Aviv University School of MedicineTel AvivIsrael
  4. 4.Department of RadiologyUniversity of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science CenterMadisonUSA

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