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Abdominal Radiology

, Volume 42, Issue 5, pp 1493–1500 | Cite as

Diffusion tensor imaging of the renal cortex in diabetic patients: correlation with urinary and serum biomarkers

  • Ahmed Abdel Khalek Abdel Razek
  • Mohammad Alsayed Abd Alhamid Al-Adlany
  • Alhadidy Mohammed Alhadidy
  • Mohammed Ali Atwa
  • Naglaa Elsayed Abass Abdou
Article

Abstract

Purpose

To demonstrate role of diffusion tensor imaging of the kidney in diabetic patients and to correlate renal fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the renal cortex with urinary and serum biomarkers of diabetes.

Material and methods

Prospective study was conducted upon 42 diabetic patients (28 males, 14 females; mean age = 33 years) and 17 age- and sex-matched volunteers. Diabetic patients were micro-normoalbuminuric (n = 27) and macroalbuminuric (n = 15). Patients and volunteers underwent diffusion tensor imaging of the kidney. The FA and ADC of the renal cortex were calculated from 3 regions of interests of both kidneys.

Results

The mean FA and ADC of the renal cortex in diabetic patients (0.36 ± 0.10 and 1.74 ± 0.16 × 10−3 mm2/s) was significantly different (p = 0.001) from that of volunteers (0.26 ± 0.02 and 1.88 ± 0.03 × 10−3 mm2/s). The cut-off renal FA and ADC used to differentiate diabetic patients from volunteers were 0.28 and 1.89 × 10−3 mm2/s with AUC of 0.791 and 0.773 and accuracy of 71% and 76%. The FA and ADC calculated in the renal cortex in patients with macroalbuminuria (0.43 ± 0.10 and 1.63 ± 0.19 × 10−3 mm2/s) was significantly different (p = 0.001) from that of patients with micro-normoalbuminuria (0.35 ± 0.12 and 1.80 ± 0.18 × 10−3 mm2/s). The FA and ADC of the renal cortex in diabetic patients correlated with urinary albumin (r = 0.530; p = 0.001, r = −0.421; p = 0.006), urinary NAG (r = 0.376; p = 0.014, r = −0.245; p = 0.01), urinary TGF-β1 (r = 0.287; p = 0.065, r = −0.214; p = 0.175), and serum creatinine (r = 0.381; p = 0.013, r = −0.349; p = 0.023).

Conclusion

The FA and ADC of the renal cortex may help in differentiation of diabetic kidney from volunteers and prediction of the presence of macroalbuminuria in diabetic patients and correlated with some of the urinary and serum biomarkers of diabetes.

Keywords

Diffusion Tensor MR imaging Diabetic Kidney 

Abbreviations

ADC

Apparent diffusion coefficient

FA

Fractional anisotropy

NAG

N-acetyl-β-d-glucosaminidase

TGF-β1

Transforming growth factor beta-1

Notes

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Ahmed Abdel Khalek Abdel Razek
    • 1
  • Mohammad Alsayed Abd Alhamid Al-Adlany
    • 2
  • Alhadidy Mohammed Alhadidy
    • 2
  • Mohammed Ali Atwa
    • 3
  • Naglaa Elsayed Abass Abdou
    • 2
  1. 1.Department of Diagnostic RadiologyMansoura Faculty of MedicineMansouraEgypt
  2. 2.Internal Medicine HospitalMansoura Faculty of MedicineMansouraEgypt
  3. 3.Department of Clinical PathologyMansoura Faculty of MedicineMansouraEgypt

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