Abdominal Radiology

, Volume 41, Issue 1, pp 33–41 | Cite as

Prognostic significance of parameters from pretreatment 18F-FDG PET in hepatocellular carcinoma: a meta-analysis

  • Da-Wei Sun
  • Lin An
  • Feng Wei
  • Lin Mu
  • Xiao-Ju Shi
  • Chuan-Lei Wang
  • Zheng-Wei Zhao
  • Teng-Fei Li
  • Guo-Yue LvEmail author
Review Paper



The prognostic value of 18F-deoxyglucose positron emission tomography (18F-FDG PET) on hepatocellular carcinoma (HCC) remains inconclusive. This study aims to investigate the prognostic role of pretreatment 18F-FDG PET on HCC patients by meta-analysis.


PubMed, Embase, Cochrane library, and Wanfang databases were searched until June 2015. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were synthesized by Stata 10.0, and the combined results were used as effective values.


Twenty-two studies containing a total of 1721 patients were identified. According to random-effect model, meta-analysis results showed that high Tumor SUV/Liver SUV (Tsuv/Lsuv) ratio was significantly associated with poorer overall survival (OS) (HR = 2.04; 95% CI 1.50–2.79; P = 0.000) and poorer disease-free survival (HR = 7.17; 95% CI 3.58–14.36; P = 0.000); and high Tumor SUV (Tsuv) value was also correlated with poor OS (HR = 1.53; 95% CI 1.26–1.87; P = 0.000). Meanwhile, subgroup analysis results showed that the significant association above was not altered by study sample size, parameter cutoff value, analytic method, and follow-up period, but there was no significant association between Tsuv/Lsuv ratio and OS in patients who underwent resection (HR = 1.71; 95% CI 1.00–2.92; P = 0.052).


Both high Tsuv/Lsuv ratio and high Tsuv value are associated with poor prognosis in HCC patients. Therefore, pretreatment 18F-FDG PET is a useful tool in predicting the prognosis of HCC patients. More studies with explicit treatment modalities are required to investigate the prognostic value of pretreatment 18F-FDG PET on HCC patients.


Hepatocellular carcinoma (HCC) 18F-deoxyglucose positron emission tomography (18F-FDG PET) Tumor SUV/Liver SUV (Tsuv/Lsuv) Tumor SUV (Tsuv) Prognosis Meta-analysis 



This work was supported by research funding from Jilin Provincial Science & Technology Department (No. 20130413021GH).

Compliance with Ethical Standards

Conflicts of Interest



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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Da-Wei Sun
    • 1
  • Lin An
    • 2
  • Feng Wei
    • 1
  • Lin Mu
    • 3
  • Xiao-Ju Shi
    • 1
  • Chuan-Lei Wang
    • 1
  • Zheng-Wei Zhao
    • 1
  • Teng-Fei Li
    • 1
  • Guo-Yue Lv
    • 1
    Email author
  1. 1.Department of Hepatobiliary and Pancreatic SurgeryThe First Hospital of Jilin UniversityChangchunChina
  2. 2.Department of DermatologyChina-Japan Union Hospital of Jilin UniversityChangchunChina
  3. 3.Department of RadiologyThe First Hospital of Jilin UniversityChangchunChina

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