Abdominal Imaging

, Volume 40, Issue 7, pp 2306–2312 | Cite as

Liver parenchyma at the site of hypodense parafissural pseudolesion contains increased collagen

  • Lianne J. P. Sonnemans
  • Nils Köster
  • Mathias Prokop
  • Jeroen A. W. M. van der Laak
  • Willemijn M. KleinEmail author



To identify a histological substrate explaining the hypodense pseudolesion in the liver at the right side of the falciform ligament and the correlation with CT radiodensity.

Materials and methods

Tissue specimens were obtained from the right (pseudolesion) and left (control) side of the falciform ligament at the level of the left portal vein, in deceased adults during autopsy. Radiodensity was measured at the same locations at CT. Digital image analysis determined the amount of collagen and fat in histological sections, and the number of portal triads and central veins were counted. Glycogen content was visually assessed by the area percentage of the histological section.


Specimens from 17 patients showed a 39% increase in collagen for the site of the pseudolesion compared to the contralateral side (p = 0.08). No significant differences were found for the amount of fat, glycogen, portal triads, or central veins. In one patient a pseudolesion was visible on CT, and this contained 52% more collagen than the control side.


The pseudolesion at the right parafissural side in the liver contains more collagen compared to the control left side, while there is no difference in fat or glycogen content or number of portal and hepatic veins. Collagen may be the cause of the pseudolesion.


Liver Computer tomography Pseudolesion Histology 



Computed tomography


Magnetic resonance imaging


Periodic acid Schiff


Hematoxylin and eosin


Elastin Van Gieson


Hounsfield unit


Post-mortem interval


Intraclass correlation coefficient


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Lianne J. P. Sonnemans
    • 1
  • Nils Köster
    • 2
  • Mathias Prokop
    • 1
  • Jeroen A. W. M. van der Laak
    • 2
  • Willemijn M. Klein
    • 1
    Email author
  1. 1.Department of Radiology and Nuclear MedicineRadboud University Medical CentreNijmegenThe Netherlands
  2. 2.Department of PathologyRadboud University Medical CentreNijmegenThe Netherlands

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