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Abdominal Imaging

, Volume 40, Issue 1, pp 56–63 | Cite as

Alveolar echinococcosis: correlation between hepatic MRI findings and FDG-PET/CT metabolic activity

  • Amel Azizi
  • Oleg Blagosklonov
  • Ahmed Lounis
  • Louis Berthet
  • Dominique-Angèle Vuitton
  • Solange Bresson-Hadni
  • Eric DelabrousseEmail author
Article

Abstract

Objective

To correlate the appearance of alveolar echinococcosis (AE) hepatic lesions in magnetic resonance imaging (MRI) as defined by Kodama, to the metabolic activity visualized in 18-fluoro-deoxyglucose positron emission tomography combined with computed tomography (PET/CT).

Materials and methods

Forty-two patients diagnosed with AE and who underwent both MRI and PET/CT were included. The forty-two hepatic lesions were divided into five types according to Kodama’s classification by three independent readers blinded with regard to the PET/CT information. Concerning PET/CT, two independent readers, unaware of the MRI information, considered the results as positive when an increased FDG-uptake was observed at 1 or 3 h after FDG-injection, and as negative when no increased uptake was noted. Inter-observer agreement was assessed by using κ statistics.

Results

Forty-two lesions were counted and the mean diameter of overall evaluated lesions was 6.3 cm. One lesion (2.4%) was categorized as type 1, 11 (26.2%) as type 2, 24 (57.1%) as type 3, 3 (7.1%) as type 4, and 3 (7.1%) as type 5. The inter-observer analysis found a κ coefficient of 0.96. All type-1, 90.9% of type-2 and 87.5% of type-3 lesions showed an increased FDG-uptake on PET/CT images. All non-microcystic AE liver lesions (types 4 and 5) showed no abnormal increased FDG-uptake on PET/CT images. The inter-observer analysis at 1 and 3 h found a κ coefficient of 0.95 and 0.92, respectively.

Conclusions

In patients with AE liver lesions, the absence of microcysts on MRI is strongly correlated to a metabolically inactive disease.

Keywords

Alveolar echinococcosis Liver MRI FDG-PET/CT Metabolic activity 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Amel Azizi
    • 1
  • Oleg Blagosklonov
    • 2
    • 3
  • Ahmed Lounis
    • 1
  • Louis Berthet
    • 2
  • Dominique-Angèle Vuitton
    • 4
  • Solange Bresson-Hadni
    • 4
  • Eric Delabrousse
    • 1
    • 3
    Email author
  1. 1.Department of RadiologyUniversity HospitalBesançonFrance
  2. 2.Departmentof Nuclear MedicineUniversity HospitalBesançonFrance
  3. 3.EA 4662 Nanomedicine Lab, Imagery and TherapeuticsUniversity of Franche-ComtéBesançonFrance
  4. 4.WHO Collaborating Centre for Prevention and Treatment of Human EchinococcosisBesançonFrance

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