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Abdominal Imaging

, Volume 39, Issue 5, pp 1009–1013 | Cite as

Prevalence of sporadic renal angiomyolipoma: a retrospective analysis of 61,389 in- and out-patients

  • Astrid Fittschen
  • Inka Wendlik
  • Suemeyra Oeztuerk
  • Wolfgang Kratzer
  • Atilla S. Akinli
  • Mark M. Haenle
  • Tilmann Graeter
Article

Abstract

Purpose

To calculate the prevalence, localization, and growth of sporadic angiomyolipomas and to identify the predominant sex in the largest patient population reviewed to date.

Methods

Abdominal ultrasound analyses of 61,389 patients (49.7% women; 50.3% men) were consecutively collected using a PC-based, standardized documentation system from September 1999 to December 2012. The present study evaluates and presents this data.

Results

The population studied includes 270 cases of sporadic angiomyolipoma (184 females; 86 males). This represents an overall prevalence of 0.44%, with 0.60% in the female and 0.28% in the male subpopulations. Mean tumor size was 10.8 ± 5.8 mm. Fifty-seven percent of cases involved the right kidney and 43.0% the left kidney. Only 14 of the 270 patients presented with multiple angiomyolipomas, four of which were bilateral. Sixty-one cases were followed over a mean period of 25 months (range: 1–105 months) and showed no significant increase in tumor size during the period of observation.

Conclusion

The analysis of 61,389 patients revealed a higher prevalence of sporadic angiomyolipoma than previously observed in smaller studies. There was a significantly higher prevalence in females than in males. Multiple and bilateral angiomyolipomas were rare, and tumor growth was marginal.

Keywords

Angiomyolipoma Sporadic kidney neoplasms 

References

  1. 1.
    Kutikov A, Fossett LK, Ramchandani P, et al. (2006) Incidence of benign pathologic findings at partial nephrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperative imaging. Urology 68:737–740PubMedCrossRefGoogle Scholar
  2. 2.
    Snyder ME, Bach A, Kattan MW, et al. (2006) Incidence of benign lesions for clinically localized renal masses smaller than 7 cm in radiological diameter: influence of sex. J Urol 176:2391–2395 (discussion 2395–2396).Google Scholar
  3. 3.
    Nelson CP, Sanda MG (2002) Contemporary diagnosis and management of renal angiomyolipoma. J Urol 168:1315–1325PubMedCrossRefGoogle Scholar
  4. 4.
    Halpenny D, Snow A, McNeill G, Torreggiani WC (2010) The radiological diagnosis and treatment of renal angiomyolipoma-current status. Clin Radiol 65:99–108PubMedCrossRefGoogle Scholar
  5. 5.
    Fujii Y, Ajima J, Oka K, Tosaka A, Takehara Y (1995) Benign renal tumors detected among healthy adults by abdominal ultrasonography. Eur Urol 27:124–127PubMedGoogle Scholar
  6. 6.
    Hajdu SI, Foote FW Jr (1969) Angiomyolipoma of the kidney: report of 27 cases and review of the literature. J Urol 102:396–401PubMedGoogle Scholar
  7. 7.
    De Luca S, Terrone C, Rossetti SR (1999) Management of renal angiomyolipoma: a report of 53 cases. BJU Int 83:215–218PubMedCrossRefGoogle Scholar
  8. 8.
    Lemaitre L, Claudon M, Dubrulle F, Mazeman E (1997) Imaging of angiomyolipomas. Semin Ultrasound CT MR 18:100–114PubMedCrossRefGoogle Scholar
  9. 9.
    Mues AC, Palacios JM, Haramis G, et al. (2010) Contemporary experience in the management of angiomyolipoma. J Endourol 24:1883–1886PubMedCrossRefGoogle Scholar
  10. 10.
    Oesterling JE, Fishman EK, Goldman SM, Marshall FF (1986) The management of renal angiomyolipoma. J Urol 135:1121–1124PubMedGoogle Scholar
  11. 11.
    Steiner MS, Goldman SM, Fishman EK, Marshall FF (1993) The natural history of renal angiomyolipoma. J Urol 150:1782–1786PubMedGoogle Scholar
  12. 12.
    Yamakado K, Tanaka N, Nakagawa T, et al. (2002) Renal angiomyolipoma: relationships between tumor size, aneurysm formation, and rupture. Radiology 225:78–82PubMedCrossRefGoogle Scholar
  13. 13.
    Jinzaki M, Silverman SG, Akita H, et al. (2014) Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management. Abdom Imaging. doi: 10.1007/s00261-014-0083-3
  14. 14.
    Jinzaki M, Ohkuma K, Tanimoto A, et al. (1998) Small solid renal lesions: usefulness of power Doppler US. Radiology 209:543–550PubMedCrossRefGoogle Scholar
  15. 15.
    Lane BR, Aydin H, Danforth TL, et al. (2008) Clinical correlates of renal angiomyolipoma subtypes in 209 patients: classic, fat poor, tuberous sclerosis associated and epithelioid. J Urol 180:836–843PubMedCrossRefGoogle Scholar
  16. 16.
    Boorjian SA, Sheinin Y, Crispen PL, et al. (2008) Hormone receptor expression in renal angiomyolipoma: clinicopathologic correlation. Urology 72:927–932PubMedCrossRefPubMedCentralGoogle Scholar
  17. 17.
    Henske EP, Ao X, Short MP, et al. (1998) Frequent progesterone receptor immunoreactivity in tuberous sclerosis-associated renal angiomyolipomas. Mod Pathol 11:665–668PubMedGoogle Scholar
  18. 18.
    Nofech-Mozes S, Vella ET, Dhesy-Thind S, et al. (2012) Systematic review on hormone receptor testing in breast cancer. Appl Immunohistochem Mol Morphol 20:214–263PubMedCrossRefGoogle Scholar
  19. 19.
    Renoir JM, Marsaud V, Lazennec G (2013) Estrogen receptor signaling as a target for novel breast cancer therapeutics. Biochem Pharmacol 85:449–465PubMedCrossRefGoogle Scholar
  20. 20.
    Zapardiel I, Delafuente-Valero J, Bajo-Arenas JM (2011) Renal angiomyolipoma during pregnancy: review of the literature. Gynecol Obstet Invest 72:217–219PubMedCrossRefGoogle Scholar
  21. 21.
    Gould Rothberg BE, Grooms MC, Dharnidharka VR (2006) Rapid growth of a kidney angiomyolipoma after initiation of oral contraceptive therapy. Obstet Gynecol 108:734–736PubMedCrossRefGoogle Scholar
  22. 22.
    Torella M, La Rezza F, Labriola D, et al. (2013) Phytoestrogens and menopause. Minerva Ginecol 65:679–696PubMedGoogle Scholar
  23. 23.
    Hobarth K, Klingler HC, Kuber W, Kratzik C (1993) Value of routine sonography in the diagnosis and conservative management of renal angiomyolipoma. Eur Urol 24:239–243PubMedGoogle Scholar
  24. 24.
    Ouzaid I, Autorino R, Fatica R, et al. (2013) Active surveillance for renal angiomyolipoma: outcomes and predictive factors of delayed intervention. BJU Int. doi: 10.1111/bju.12604
  25. 25.
    Charboneau JW, Hattery RR 3rd, Ernst EC, et al. (1983) Spectrum of sonographic findings in 125 renal masses other than benign simple cyst. AJR Am J Roentgenol 140:87–94PubMedCrossRefGoogle Scholar
  26. 26.
    Goldman SM (1989) Benign renal tumors: diagnosis and treatment. Urol Radiol 11:203–209PubMedCrossRefGoogle Scholar
  27. 27.
    Jinzaki M, Tanimoto A, Narimatsu Y, et al. (1997) Angiomyolipoma: imaging findings in lesions with minimal fat. Radiology 205:497–502PubMedCrossRefGoogle Scholar
  28. 28.
    Kim JY, Kim JK, Kim N, Cho KS (2008) CT histogram analysis: differentiation of angiomyolipoma without visible fat from renal cell carcinoma at CT imaging. Radiology 246:472–479PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Astrid Fittschen
    • 1
  • Inka Wendlik
    • 2
  • Suemeyra Oeztuerk
    • 1
  • Wolfgang Kratzer
    • 1
  • Atilla S. Akinli
    • 1
  • Mark M. Haenle
    • 1
  • Tilmann Graeter
    • 2
  1. 1.Department of Internal Medicine IUniversity Hospital UlmUlmGermany
  2. 2.Department of Interventional and Diagnostic RadiologyUniversity Hospital UlmUlmGermany

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