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Abdominal Imaging

, Volume 38, Issue 3, pp 543–549 | Cite as

Autoimmune pancreatitis: whole-body 18F-FDG PET/CT findings

  • Jian Zhang
  • Chengwei Shao
  • Jianhua Wang
  • Chao Cheng
  • Changjing ZuoEmail author
  • Gaofeng Sun
  • Bin Cui
  • Aisheng Dong
  • Qinghua Liu
  • Lingshan Kong
Article

Abstract

Purpose

The study aimed to investigate the function of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing of autoimmune pancreatitis (AIP) and whole-body evaluation.

Methods

Seven AIP patients who underwent 18F-FDG PET/CT systemic examination in our hospital from August 2010 to March 2012 were analyzed retrospectively. Systemic PET/CT routine scanning and pancreatic delayed scanning were performed in all patients.

Results

The mean age of 7 AIP patients (6 male and 1 female) was 54.2 years (range from 42 to 71 years). The pancreas showed diffuse enlargement in 6 cases, and segmental enlargement in 1 case. Fluorodeoxyglucose (FDG) uptake was increased in diseased region. The maximum standardized uptake value (SUVmax) was 4.38 ± 0.90 and increased to 5.31 ± 1.08 after delayed scanning, of which small amounts of inflammatory exudate around pancreas was observed in 4 cases. Extrapancreatic lesions (EPLs) were observed in all 7 cases: lymphadenectasis (n = 5), lymphadenectasis with increased FDG uptake (n = 4); associated sialosis with metabolism enlargement (n = 4); associated cholangitis (n = 4); associated interstitial pneumonia (n = 3); inverted “V” shaped high FDG uptake foci in prostate (n = 5).

Conclusions

AIP is a systemic disease. 18F-FDG PET/CT can exhibit the characteristics of AIP pancreatic lesions, and also better reflect the changes and metabolic characteristics of extrapancreatic organs. It plays a distinct role in diagnosis, differentiating of AIP and whole-body evaluation.

Keywords

Autoimmune diseases Autoimmune pancreatitis Pancreas 18F-FDG PET/CT 

Notes

Acknowledgments

This study is funded by China Postdoctoral Science Foundation (20100480545); The International Cooperation projects of Shanghai Science and Technology Committee (10410708800); National Natural Science Foundation of China (81170435); Natural Science Foundation of Ningbo, China (2010A610052).

References

  1. 1.
    Finkelberg DL, Sahani D, Deshpande V, et al. (2006) Autoimmune pancreatitis. N Engl J Med 355:2670–2676PubMedCrossRefGoogle Scholar
  2. 2.
    Kamisawa T, Okamoto A (2006) Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease. J Gastroenterol 41:613–625PubMedCrossRefGoogle Scholar
  3. 3.
    Kamisawa T, Takum K, Anjiki H, et al. (2010) FDG-PET/CT findings of autoimmune pancreatitis. Hepatogastroenterology 57:447–450PubMedGoogle Scholar
  4. 4.
    Sato M, Okumura T, Shioyama Y, et al. (2008) Extrapancreatic F-18 FDG accumulation in autoimmune pancreatitis. Ann Nucl Med 22:215–219PubMedCrossRefGoogle Scholar
  5. 5.
    Shimosegawa T, Chari ST, Frulloni L, et al. (2011) International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas 40:352–358PubMedCrossRefGoogle Scholar
  6. 6.
    Sánchez-Castañón M, de las Heras-Castaño G, López-Hoyos M (2010) Autoimmune pancreatitis: an underdiagnosed autoimmune disease with clinical, imaging and serological features. Autoimmun Rev 9:237–240PubMedCrossRefGoogle Scholar
  7. 7.
    Hamano H, Arakura N, Muraki T, et al. (2006) Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis. J Gastroenterol 41:1197–1205PubMedCrossRefGoogle Scholar
  8. 8.
    Kamisawa T, Shimosegawa T, Okazaki K, et al. (2009) Standard steroid treatment for autoimmune pancreatitis. Gut 58:1504–1507PubMedCrossRefGoogle Scholar
  9. 9.
    Tanaka S, Kobayashi T, Nakanishi K, et al. (2000) Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis. Lancet 356:910–911PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Jian Zhang
    • 1
  • Chengwei Shao
    • 2
  • Jianhua Wang
    • 1
  • Chao Cheng
    • 1
  • Changjing Zuo
    • 1
    Email author
  • Gaofeng Sun
    • 1
  • Bin Cui
    • 1
  • Aisheng Dong
    • 1
  • Qinghua Liu
    • 1
  • Lingshan Kong
    • 1
  1. 1.Department of Nuclear Medicine, Changhai HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Department of Radiology, Changhai HospitalSecond Military Medical UniversityShanghaiChina

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