Autoimmune pancreatitis: whole-body 18F-FDG PET/CT findings
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The study aimed to investigate the function of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing of autoimmune pancreatitis (AIP) and whole-body evaluation.
Seven AIP patients who underwent 18F-FDG PET/CT systemic examination in our hospital from August 2010 to March 2012 were analyzed retrospectively. Systemic PET/CT routine scanning and pancreatic delayed scanning were performed in all patients.
The mean age of 7 AIP patients (6 male and 1 female) was 54.2 years (range from 42 to 71 years). The pancreas showed diffuse enlargement in 6 cases, and segmental enlargement in 1 case. Fluorodeoxyglucose (FDG) uptake was increased in diseased region. The maximum standardized uptake value (SUVmax) was 4.38 ± 0.90 and increased to 5.31 ± 1.08 after delayed scanning, of which small amounts of inflammatory exudate around pancreas was observed in 4 cases. Extrapancreatic lesions (EPLs) were observed in all 7 cases: lymphadenectasis (n = 5), lymphadenectasis with increased FDG uptake (n = 4); associated sialosis with metabolism enlargement (n = 4); associated cholangitis (n = 4); associated interstitial pneumonia (n = 3); inverted “V” shaped high FDG uptake foci in prostate (n = 5).
AIP is a systemic disease. 18F-FDG PET/CT can exhibit the characteristics of AIP pancreatic lesions, and also better reflect the changes and metabolic characteristics of extrapancreatic organs. It plays a distinct role in diagnosis, differentiating of AIP and whole-body evaluation.
KeywordsAutoimmune diseases Autoimmune pancreatitis Pancreas 18F-FDG PET/CT
This study is funded by China Postdoctoral Science Foundation (20100480545); The International Cooperation projects of Shanghai Science and Technology Committee (10410708800); National Natural Science Foundation of China (81170435); Natural Science Foundation of Ningbo, China (2010A610052).