Abdominal Imaging

, Volume 36, Issue 4, pp 372–381 | Cite as

Inflammatory bowel disease: value in diagnosis and management of MDCT-enteroclysis and 99mTc-HMPAO labeled leukocyte scintigraphy

  • Roberto Grassi
  • Pier Francesco Rambaldi
  • Graziella Di Grezia
  • Luigi Mansi
  • Vincenzo Cuccurullo
  • Amalia Cirillo
  • Gabriele Riegler
  • Salvatore Cappabianca
  • Antonio Rotondo
Article

Abstract

Objectives

The aims of this study are: (a) to evaluate the reliability of Multidetector Computed Tomography Enteroclysis (MDCT-E) and 99mTc-HMPAO labeled leukocyte scintigraphy (TLLS), in inflammatory bowel disease, (b) to test the accuracy of the two techniques with regard to their histological results, (c) to define how each technique can influence the natural course of inflammatory bowel disease (IBD), (d) to assess the potential value of the two techniques combined.

Materials and methods

Thirty-seven patients with suspected IBD underwent MDCT-E and TLLS. We made a separate assessment of the results shown by the two methods and then compared and contrasted the histological results of the two. The latter, however, were either disappointing or not available in 15 patients who, for this reason, had to be dismissed from the study. As result, the number of participants eventually dropped to 22 subjects: 12 women, 10 men with an average age of 44 years.

Results

MDCT-E and TLLS were successful in all patients. Sensitivity, specificity, and efficiency values have been reported as follows:
  • MDCT-E: 62%, 100%, 64%,100%, 11%, respectively.

  • TLLS: 90%, 100%, 91%, 100%, 33%, respectively.

  • The two methods combined: 95%, 100%, 95%, 100%, 50%, respectively.

Conclusions

The two techniques can be employed in different stages of the natural course of the disease. In our experience, TLLS proved itself to be useful in the diagnosis of the disease and the assessment of its development. Conversely, MDCT-E proved itself to be more reliable in identifying the seat and the extent of the disease inside and outside the bowel wall as well as potential intra-peritoneal and extra-intestinal complications. The combined use of the two methods represents the Criterion Standard for diagnosing IBD with imaging.

Key words

Multidetector Computed Tomography Enteroclysis 99mTc-HMPAO labeled leukocyte scintigraphy Inflammatory bowel disease Crohn’s disease Ulcerative colitis 

Notes

Acknowledgments

We are greatly indebted to Carlo Macchia for language consultancy.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Roberto Grassi
    • 1
  • Pier Francesco Rambaldi
    • 1
  • Graziella Di Grezia
    • 2
  • Luigi Mansi
    • 1
  • Vincenzo Cuccurullo
    • 1
  • Amalia Cirillo
    • 3
  • Gabriele Riegler
    • 3
  • Salvatore Cappabianca
    • 1
  • Antonio Rotondo
    • 1
  1. 1.SUN, Diagnostic ImagingNaplesItaly
  2. 2.Diagnostic Imaging DepartmentSecond University of NaplesNaplesItaly
  3. 3.SUN, GastroenterologyNaplesItaly

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