Abdominal Imaging

, Volume 35, Issue 6, pp 757–763

Peripheral zone prostate cancer. Pre-treatment evaluation with MR and 3D 1H MR spectroscopic imaging: correlation with pathologic findings

  • Sabina Giusti
  • Davide Caramella
  • Elena Fruzzetti
  • Michele Lazzereschi
  • Adele Tognetti
  • Carlo Bartolozzi
Article

Abstract

The purpose of this study was to retrospectively characterize benign and malignant prostate peripheral zone tissue by using endorectal MRI and 3D 1H MRS. Fifty-two men with untreated biopsy-proven prostate cancer underwent combined endorectal MRI and MRSI. Whole-mount step-section histopathologic analysis constituted the reference standard. Biopsy correctly detected 74 locations; MRI correctly detected 72 locations; MRS correctly detected 72 locations; MRI + MRS correctly detected 78 locations. Cohen’s test showed that biopsy had a lower degree of agreement with histology than MRI + MRS combined. The ratio of [(Cho + Cr)]/Cit correlates with the pathologic Gleason score. The addition of 3D1H MRSI to MRI can improve diagnosis of prostate cancer contributing indirectly to improve local staging. In addition, the correlation between metabolic 3D1H MRSI data with pathological Gleason grade may offer a non-invasive means to better predict prostate cancer aggressiveness.

Keywords

Prostate Cancer MRI Spectroscopy Endorectal MRI 

References

  1. 1.
    Quinn M, Babb P (2002) Patterns and trends in prostate cancer incidence, survival prevalence and mortality. Part I. International comparisons. BJU Int 90:162–173CrossRefPubMedGoogle Scholar
  2. 2.
    Levi F, Lucchini F, Negri E, et al. (2004) Leveling of prostate cancer mortality in Western Europe. Prostate 60:46–52CrossRefPubMedGoogle Scholar
  3. 3.
    Westphalen AC, Coakley FV, Qayyum A, et al. (2008) Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging. Radiology 246(1):177–184CrossRefPubMedGoogle Scholar
  4. 4.
    Bostwick DG, Graham SD Jr, Sapalkov P, et al. (1993) Staging of early prostate cancer: a proposed tumor volume-based prognostic index. Urology 41:403–411CrossRefPubMedGoogle Scholar
  5. 5.
    Coakley FV, Kurhanewicz J, Li Y, et al. (2002) Prostate cancer tumor volume: measurement by endorectal MR imaging and MR spectroscopic imaging. Radiology 223:91–97CrossRefPubMedGoogle Scholar
  6. 6.
    Scheidler J, Hricak H, Vigneron DB, et al. (1999) Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging—clinicopathologic study. Radiology 213:473–480PubMedGoogle Scholar
  7. 7.
    Kurhanewicz J, Swanson MG, Nelson SJ, et al. (2002) Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer. J Magn Reson Imaging 16:451–463CrossRefPubMedGoogle Scholar
  8. 8.
    Fütterer JJ, Engelbrecht MR, Jager GJ, et al. (2007) Prostate cancer: comparison of local staging accuracy of pelvic phased-array coil alone versus integrated endorectal-pelvic phased-array coils. Local staging accuracy of prostate cancer using endorectal coil MR imaging. Eur Radiol 17(4):1055–1065CrossRefPubMedGoogle Scholar
  9. 9.
    Stokes SH, Real JD, Adams PW, et al. (1997) Transperineal ultrasound-guided radioactive seed implantation for organ-confined carcinoma of the prostate. Int J Radiat Oncol Biol Phys 37:337–341PubMedGoogle Scholar
  10. 10.
    Amin Z, Lees WR, Bown SG (1993) Technical note: interstitial laser photocoagulation for the treatment of prostatic cancer. Br J Radiol 66:1044–1047CrossRefPubMedGoogle Scholar
  11. 11.
    Lee F, Bahn DK, McHugh TA, et al. (1994) US-guided percutaneous cryoablation of prostate cancer. Radiology 192:769–776PubMedGoogle Scholar
  12. 12.
    Chodak GW, Thisted RA, Gerber GS, et al. (1994) Results of conservative management of clinically localized prostate cancer. N Engl J Med 330:242–248CrossRefPubMedGoogle Scholar
  13. 13.
    Hom JJ, Coakley FV, Simko JP, et al. (2007) High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features–initial experience. Radiology 242(2):483–489CrossRefPubMedGoogle Scholar
  14. 14.
    Engeler CE, Wasserman NF, Zhang G (1992) Preoperative assessment of prostatic carcinoma by computerized tomography. Weaknesses and new perspectives. Urology 490:346–349CrossRefGoogle Scholar
  15. 15.
    Vigneron DB, Males R, Noworolski S, et al. (1998) 3D MRSI of prostate cancer: correlation with histologic grade (abstr) In: Proceedings of the sixth meeting of the international society for magnetic resonance in medicine. Berkeley, Calif: International Society for Magnetic Resonance in Medicine, p 487Google Scholar
  16. 16.
    Quayyum A, Coakley FV, Lu Y, et al. (2004) Organconfined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging. AJR Am J Roentgenol 183:1079–1083Google Scholar
  17. 17.
    Horndalsveen Berild G, Nielsen K (1986) Accuracy in core biopsy of the prostate. An autopsy study. Urol Int 41:276CrossRefPubMedGoogle Scholar
  18. 18.
    Öbek C, Louis P, Civantos F, et al. (1999) Comparison of digital rectal examination, biopsy results with the radical prostatectomy specimen. J Urol 161:494CrossRefPubMedGoogle Scholar
  19. 19.
    Salomon L, Colombel M, Patard JJ, et al. (1999) Value of ultrasound-guided systematic sextant biopsies in prostate tumor mapping. Eur Urol 35:289CrossRefPubMedGoogle Scholar
  20. 20.
    Slawin KM, Ohori M, Dillioglugil O, et al. (1995) Screening for prostate cancer: an analysis of the early experience. CA Cancer J Clin 45:134–138CrossRefPubMedGoogle Scholar
  21. 21.
    Yu KK, Hricak H, Alagappan R, et al. (1997) Detection of extracapsular extension of prostate carcinoma with endorectal, phased-array coil MR imaging multivariate feature analysis. Radiology 202:697PubMedGoogle Scholar
  22. 22.
    Zelefsky MJ, Fuks Z, Leibel SA (2002) Intensity-modulated radiation therapy for prostate cancer. Semin Radiat Oncol 12:229–237CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sabina Giusti
    • 1
  • Davide Caramella
    • 2
  • Elena Fruzzetti
    • 1
  • Michele Lazzereschi
    • 1
  • Adele Tognetti
    • 3
  • Carlo Bartolozzi
    • 1
  1. 1.Division of RadiologyUniversity of PisaPisaItaly
  2. 2.Division of Diagnostic and Interventional RadiologyUniversity of PisaPisaItaly
  3. 3.Division of PathologyUniversity of PisaPisaItaly

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