Abdominal Imaging

, Volume 29, Issue 2, pp 224–227 | Cite as

Acute, complete splenic infarction in cancer patient is associated with a fatal outcome

Original article


Splenic infarction frequently occurs in patients with myeloproliferative diseases, endocarditis, and sickle cell anemia. Various sonographic patterns of splenic infarction do exist, but little is known about tumor associated splenic infarction in cancer patients. Between January 1992 and December 2002, 66 patients were diagnosed with splenic infarction by color Doppler sonography (CDS). Ten patients had an underlying solid cancer. Clinical and sonographic data of cancer patients were evaluated retrospectively with regard to age, sex, frequency of thrombotic episodes, splenic size, echomorphology and vascularity of splenic lesions, and follow-up examination. The median age was 53 years (range, 16–73 years). Nine of 10 patients had abdominal metastases, four had evidence of a hypercoagulable state, five had a small spleen (< 7 × 3 cm), and seven had acute complete infarction of the spleen without hilar and parenchymal vessels on CDS. Survival of six patients with acute complete infarction ranged from 1 to 30 days. In cancer patients with splenic infarction, an acute complete infarction is the most common pattern. It is caused predominantly by a hypercoagulable state and is associated with an extremely short survival.


Cancer Splenic infarction Ultrasound 


  1. 1.
    Levine, M 1997Treatment of thrombotic disorders in cancer patients.Haemostasis2738PubMedGoogle Scholar
  2. 2.
    Schäfer, AL 1984Bleeding and thrombosis in the myeloproliferative disorders.Blood641PubMedGoogle Scholar
  3. 3.
    Deppisch, LM, Fayemi, AO 1976Nonbacterial thrombotic endocarditis: clinicopathologic correlations.Am Heart J92723PubMedCrossRefGoogle Scholar
  4. 4.
    Görg, C, Schwerk, WB 1990Splenic Infarction: sonographic patterns, diagnosis, follow-up, and complications.Radiology174803807Google Scholar
  5. 5.
    Görg, C, Schwerk, WB, Görg, K 1991Splenic lesions: sonographic patterns, follow-up, differential diagnosis.Eur J Radiol135966CrossRefGoogle Scholar
  6. 6.
    Weingarten, MJ, Fakhnj, I, McCarthy, I,  et al. 1984Sonography after splenic embolization: the wedge-shaped acute infarct.AJR141957959Google Scholar
  7. 7.
    Görg, C, Schwerk, WB 1994Color Doppler imaging of focal splenic masses.Eur J Radiol18214219CrossRefGoogle Scholar
  8. 8.
    Lam, KY, Tang, V 2000Metastatic tumors to the spleen: a 25 year clinicopathologic study.Arch Pathol Lab Med124526532PubMedGoogle Scholar
  9. 9.
    Görg, C, Eichkorn, M, Zugmaier, G 2003The small spleen: sonographic patterns of functional hyposplenia or asplenia.J Clin Ultrasound31152155PubMedCrossRefGoogle Scholar
  10. 10.
    Görg, C, Weide, R, Schwerck, WB 1997Malignant splenic lymphoma: sonographic patterns, diagnosis, and follow- up.Clin Radiol52535540PubMedCrossRefGoogle Scholar
  11. 11.
    Danaci, M, Belet, Ü, Yalm, T,  et al. 2000Power Doppler sonographic diagnosis of torsion in a wandering spleen.J Clin Ultrasound28246248PubMedCrossRefGoogle Scholar
  12. 12.
    Roshkow, J, Sander, LM 1990Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT, and MRT findings.Radiology177723726PubMedGoogle Scholar
  13. 13.
    Needleman, L, Kurtz, AB, Rifkin, MD,  et al. 1986Sonography of diffuse benign liver disease: accuracy of pattern recognition and grading.AJR14610111015PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 2004

Authors and Affiliations

  1. 1.Department of Internal MedicinePhilipps-University, Baldingerstrasse, 35043 MarburgGermany

Personalised recommendations