European Journal of Nuclear Medicine

, Volume 28, Issue 9, pp 1421–1429

Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives

  • Wout A. Breeman
  • Marion de Jong
  • Dik J. Kwekkeboom
  • Roelf Valkema
  • Willem H. Bakker
  • Peter P. Kooij
  • Theo J. Visser
  • Eric P. Krenning
Review Article

Abstract.

In vivo somatostatin receptor-mediated scintigraphy has proven to be a valuable method for the visualisation of neuroendocrine tumours and their metastases. A new application is the use of radiolabelled analogues for somatostatin receptor-mediated therapy. This paper presents a review on the basic science, historical background and current knowledge of somatostatin receptor subtypes and their expression in neuroendocrine tumours. New somatostatin analogues, new chelators, "new" radionuclides and combinations thereof are also discussed. Due attention is given to limitations and future perspectives of somatostatin receptor-mediated imaging and therapy.

Somatostatin receptor subtypes Imaging Therapy DTPA DOTA 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Wout A. Breeman
    • 1
  • Marion de Jong
    • 1
  • Dik J. Kwekkeboom
    • 1
  • Roelf Valkema
    • 1
  • Willem H. Bakker
    • 1
  • Peter P. Kooij
    • 1
  • Theo J. Visser
    • 2
  • Eric P. Krenning
    • 1
  1. 1.Department of Nuclear Medicine, Erasmus Medical Centre Rotterdam, 3015 GD RotterdamThe Netherlands
  2. 2.Department of Internal Medicine, Erasmus Medical Centre Rotterdam, 3015 GD RotterdamThe Netherlands

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