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European Journal of Nuclear Medicine

, Volume 27, Issue 6, pp 647–655 | Cite as

Nationwide standardisation and evaluation of scintigraphic gastric emptying: reference values and comparisons between subgroups in a multicentre trial

  • Per Grybäck
  • Gert Hermansson
  • Ebbe Lyrenäs
  • Karl-Wilhelm Beckman
  • Hans Jacobsson
  • Per M. Hellström
Original article

Abstract.

By means of a standardised procedure, reference values for scintigraphic gastric emptying were established. The influence of gender, age, menstrual cycle, body mass index (BMI) and smoking habits was also evaluated. Eight centres recruited 20 healthy subjects each. The meal consisted of a technetium-99m labelled omelet (1300 kJ) and of 150 ml unlabelled soft drink. Geometric means of frontal and dorsal acquisitions were utilised in a linear fit model for determination of the linear emptying rate, and by using the intercepts of the regression line with the 90% and 50% levels, the lag phase and half-emptying time, respectively, were defined. All individuals showed an initial lag phase and subsequent linear emptying. Because of a longer lag phase and a slower linear emptying rate, premenopausal women had a slower gastric emptying than postmenopausal women and men of all ages. The gastric emptying rate increased with age in the women, mainly due to a shortened lag phase, while the emptying rate remained almost unchanged with age in the males. There were no significant differences in results between the centres. The menstrual cycle, BMI and smoking habits did not affect emptying. In conclusion, the fact that the results showed a slower gastric emptying rate in younger women compared with older women and men indicates that it is necessary to use separate reference values for fertile females.

Key words: Standardisation Stomach Emptying Stomach Radionuclide studies 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Per Grybäck
    • 1
  • Gert Hermansson
    • 2
  • Ebbe Lyrenäs
    • 3
  • Karl-Wilhelm Beckman
    • 4
  • Hans Jacobsson
    • 1
  • Per M. Hellström
    • 5
  1. 1.Department of Radiology, Karolinska Hospital, Stockholm, SwedenSE
  2. 2.Department of Clinical Physiology, Östra Hospital, Göteborg, SwedenSE
  3. 3.Department of Medicine, Blekinge Hospital, Karlskrona, SwedenSE
  4. 4.Hospital Physics, Örebro Hospital, Örebro, SwedenSE
  5. 5.Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, SwedenSE

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