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European Journal of Nuclear Medicine

, Volume 26, Issue 8, pp 903–906 | Cite as

Use of Technegas as a radiopharmaceutical for the measurement of gastric emptying

  • Monika A. Kwiatek
  • Karen L. Jones
  • William M. Burch
  • Michael Horowitz
  • F. Dylan L. Bartholomeusz
Short communication

Abstract.

Many radiopharmaceuticals and test meals that are used to measure gastric emptying are less than optimal. A vegetable-based solid meal, such as rice, labelled with a radiopharmaceutical that also has the capacity to measure gastric emptying of liquids, is likely to be ideal. The role of Technegas as a radioisotopic marker to measure gastric emptying of rice and liquids was evaluated. Technegas-labelled rice was incubated in 0.9% saline, 1 M HCl and simulated gastric fluid (3.2 g/l pepsinogen, pH 2–3) to assess stability of the label. In eight healthy volunteers gastric emptying of two meals – 200 g rice (370 kcal) and 75 g dextrose dissolved in 300 ml water (300 kcal), both labelled with 20 MBq of Technegas – was measured scintigraphically. Over 4 h, the average label stability was 93.7%±0.5% in 0.9% saline, 91.0%±0.4% in 1 M HCl and 93.6%±0.7% in simulated gastric juice. The lag phase was longer for rice than dextrose (25±7 min vs 4±2 min; P<0.05), but there was no difference in the post-lag emptying rate (2.1±0.3 kcal/min vs 1.7±0.2 kcal/min; P=0.2) between the two meals. We conclude that Technegas is a suitable radiopharmaceutical for measurement of gastric emptying of rice and nutrient-containing liquids.

Key words: Gastric emptying Technegas Rice 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Monika A. Kwiatek
    • 1
  • Karen L. Jones
    • 1
  • William M. Burch
    • 2
  • Michael Horowitz
    • 3
  • F. Dylan L. Bartholomeusz
    • 4
  1. 1.School of Medical Radiation, University of South Australia, Adelaide, AustraliaAU
  2. 2.John Curtin School of Medical Research, Australian National University, Australian Capital Territory, AustraliaAU
  3. 3.Department of Medicine, Royal Adelaide Hospital, The University of Adelaide, Adelaide, AustraliaAU
  4. 4.Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, AustraliaAU

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