European Journal of Nuclear Medicine

, Volume 26, Issue 2, pp 171–182

Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism

  • Jan Booij
  • Gerrit Tissingh
  • Ania Winogrodzka
  • Eric A. van Royen
Review article

Abstract.

Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowadays, by using single-photon emission tomography (SPET) and positron emission tomography (PET) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine D2 receptors in vivo. Consequently, SPET and PET imaging of elements of the dopaminergic system can play an important role in the diagnosis of several parkinsonian syndromes. This review concentrates on findings of SPET and PET studies of the dopaminergic neurotransmitter system in various parkinsonian syndromes.

Key words: Single-photon emission tomography Positron emission tomography Parkinsonism Dopamine transporter imaging Dopamine D2 receptor imaging 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Jan Booij
    • 1
  • Gerrit Tissingh
    • 2
  • Ania Winogrodzka
    • 2
  • Eric A. van Royen
    • 1
  1. 1.Graduate School of Neurosciences Amsterdam, Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The NetherlandsNL
  2. 2.Graduate School of Neurosciences Amsterdam, Department of Neurology, Academisch Ziekenhuis Vrije Universiteit, De Boelelaan 1117, Amsterdam, The NetherlandsNL

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