European Journal of Nuclear Medicine

, Volume 26, Issue 1, pp 22–30 | Cite as

A PET study of 18FDG uptake in soft tissue masses

  • Martin A. Lodge
  • Jonathan D. Lucas
  • Paul K. Marsden
  • Bernadette F. Cronin
  • Michael J. O’Doherty
  • Michael A. Smith
Original article

Abstract.

A study was performed with the aim of investigating some of the methodological factors affecting the ability of quantitative 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography to assess tumour malignancy. Twenty-nine patients with soft tissue masses were studied using a 6-hour scanning protocol and various indices of glucose metabolism were compared with histological grade. Significant differences were observed in the time-activity response of benign and high-grade tumours. High-grade sarcomas were found to reach a peak activity concentration approximately 4 h after injection whereas benign lesions reached a maximum within 30 min. This translated to improved differentiation between these two tumour types using a standard uptake value (SUV) derived from images acquired at later times. An SUV measured 4 h post-injection was found to be as useful an index of tumour malignancy as the metabolic rate of FDG determined using either Patlak or non-linear regression techniques. Each of these indices had a sensitivity and specificity of 100% and 76% respectively for the discrimination of high-grade sarcomas from benign tumours.

Key words: Positron emission tomography 2-[18F]-fluoro-2-deoxy-d-glucose Soft tissue sarcoma 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Martin A. Lodge
    • 1
  • Jonathan D. Lucas
    • 2
  • Paul K. Marsden
    • 1
  • Bernadette F. Cronin
    • 1
  • Michael J. O’Doherty
    • 1
  • Michael A. Smith
    • 2
  1. 1.Clinical PET Centre, Division of Radiological Sciences, United Medical and Dental Schools of Guys & St. Thomas’ Hospitals, London, UKGB
  2. 2.Department of Orthopaedics, Guys & St. Thomas’ Hospitals, London, UKGB

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