Advertisement

European Journal of Nuclear Medicine

, Volume 28, Issue 2, pp 241–252 | Cite as

Imaging infection/inflammation in the new millennium

  • Huub J. J. M. Rennen
  • Otto C. Boerman
  • Wim J. G. Oyen
  • Frans H. M. Corstens
Review Article

Abstract

In the closing half of the past century a wide variety of approaches were developed to visualise infection and inflammation by gamma scintigraphy. Use of autologous leucocytes, labelled with indium-111 or technetium-99m, is still considered the "gold standard" nuclear medicine technique for the imaging of infection and inflammation. However, the range of radiopharmaceuticals used to investigate infectious and non-microbial inflammatory disorders is expanding rapidly. Developments in protein/peptide chemistry and in radiochemistry should lead to agents with very high specific activities. Recently, positron emission tomography with fluorine-18 fluorodeoxyglucose has been shown to delineate infectious and inflammatory foci with high sensitivity. The third millennium will witness a gradual shift from basic (non-specific) or cumbersome, even hazardous techniques (radiolabelled leucocytes) to more sophisticated approaches. Here a survey is presented of the different approaches in use or under investigation.

Imaging Infection Inflammation Gamma scintigraphy FDG-PET 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Huub J. J. M. Rennen
    • 1
  • Otto C. Boerman
    • 1
  • Wim J. G. Oyen
    • 1
  • Frans H. M. Corstens
    • 1
  1. 1.Department of Nuclear Medicine, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The NetherlandsThe Netherlands

Personalised recommendations