Recently, a type of pneumonia caused by a novel Betacoronavirus, the 2019 novel coronavirus (2019-nCoV), has spread in China, mainly in Wuhan . It is known that cases of this disease have also been identified in other provinces of China .
A 53-year-old man has lived in Wuhan for many years, and recently came to Guangzhou, China. He was admitted to the hospital with fever and cough in the last 2 days, and his highest body temperature was 38.3 °C before admission. The laboratory examinations showed decreased white blood cell count (2.50 × 109/L) and elevated C-reactive protein (16.2 mg/L; normal range 0–10 mg/L).
Non-contrast-enhanced chest computed tomography (CT) (Fig. 1a, b) showed multiple, bilateral, peripheral, patchy ground glass opacities, lobular, and subsegmental, with fading margins. The lesions had mainly a subpleural distribution.
CT also demonstrated slight thickening of the adjacent pleura (yellow arrow) and interlobular septa in the lesion (red arrow). Subsequently, the patients had laboratory-confirmed 2019-nCoV infection by real-time polymerase chain reaction (PCR). After 5 days, CT scan (Fig. 1c, d) showed enlarged lesions, compared with previous images, and progressive ground glass opacities in both lower lobes, indicating disease progression.
Infection with 2019-nCoV was confirmed based on the patient’s epidemiological history, clinical manifestations, imaging characteristics, and laboratory tests.
Bilateral, multiple, patchy, or ground glass opacities, with subpleural distribution, were the lung CT appearances of this patient, affected by 2019-nCoV pneumonia. These characteristics should be recognized by professionals working in imaging departments.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019 [J]. N Engl J Med. 2020. https://doi.org/10.1056/NEJMoa2001017.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J]. Lancet. 2020. https://doi.org/10.1016/S0140-6736(20)30183-5.
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This article is part of the Topical Collection on The Infection and Inflammation
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Xu, X., Yu, C., Zhang, L. et al. Imaging features of 2019 novel coronavirus pneumonia. Eur J Nucl Med Mol Imaging (2020). https://doi.org/10.1007/s00259-020-04720-2