Hepatic supraselective radioembolization, today and new horizons

  • Javier Orcajo RincónEmail author
  • Amanda Rotger Regi
  • Manuel González Leyte
  • Laura Carrión Martín
  • Rebeca Pérez Pascual
  • Juan Carlos Alonso Farto
Letter to the Editor
Part of the following topical collections:
  1. Oncology – Digestive tract

Dear Sir,

We read with great interest the article by Jafargholi Rangraz et al. recently published in EJNMMI Research [1], which invites reflection on the evolution of hepatic radioembolization in recent times.

Selective arterial irrigation of liver tumors, unlike portal irrigation of healthy parenchyma, served the basis for the initial intra-arterial therapies around the 1950s with the first radioembolization with Yttrium-90 (Y90) through the celiac axis not actually practiced until 1965 [2]. Then, a homogenous intra-abdominal distribution of the ceramic microspheres was indicative of therapeutic success with, surprisingly, good tolerability, low rate of complications, and symptomatic improvement [3].

It was not until the late 1980s, however, that first glass and resin microspheres were developed, and first phase 1 trials launched. Since then, transarterial radioembolization (TARE) has been used for the local treatment of primary and metastatic liver disease.

In recent decades,...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


  1. 1.
    Jafargholi Rangraz E, Coudyzer W, Maleux G, Baete K, Deroose CM, Nuyts J. Multi-modal image analysis for semi-automatic segmentation of the total liver and liver arterial perfusion territories for radioembolization. EJNMMI Res. 2019;9(1).Google Scholar
  2. 2.
    Ariel IM. Treatment of inoperable primary pancreatic and liver cancer by the intra-arterial administration of radioactive isotopes (Y90 radiating microspheres). Ann Surg. 1965;162:267–78.CrossRefGoogle Scholar
  3. 3.
    Saini A, Wallace A, Alzubaidi S, Knuttinen MG, Naidu S, Sheth R, et al. History and evolution of Yttrium-90 radioembolization for hepatocellular carcinoma. J Clin Med. 2019;8(1).Google Scholar
  4. 4.
    Riaz A, Gates VL, Atassi B, Lewandowski RJ, Mulcahy MF, Ryu RK, et al. Radiation segmentectomy: a novel approach to increase safety and efficacy of radioembolization. Int J Radiat Oncol Biol Phys. 2011;79(1):163–71.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Javier Orcajo Rincón
    • 1
    Email author
  • Amanda Rotger Regi
    • 1
  • Manuel González Leyte
    • 2
  • Laura Carrión Martín
    • 3
  • Rebeca Pérez Pascual
    • 1
  • Juan Carlos Alonso Farto
    • 1
  1. 1.Nuclear Medicine DepartmentHospital General Universitario Gregorio MarañónMadridSpain
  2. 2.Interventional Radiology DepartmentHospital General Universitario Gregorio MarañónMadridSpain
  3. 3.Gastroenterology DepartmentHospital General Universitario Gregorio MarañónMadridSpain

Personalised recommendations