Hepatic supraselective radioembolization, today and new horizons
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We read with great interest the article by Jafargholi Rangraz et al. recently published in EJNMMI Research , which invites reflection on the evolution of hepatic radioembolization in recent times.
Selective arterial irrigation of liver tumors, unlike portal irrigation of healthy parenchyma, served the basis for the initial intra-arterial therapies around the 1950s with the first radioembolization with Yttrium-90 (Y90) through the celiac axis not actually practiced until 1965 . Then, a homogenous intra-abdominal distribution of the ceramic microspheres was indicative of therapeutic success with, surprisingly, good tolerability, low rate of complications, and symptomatic improvement .
It was not until the late 1980s, however, that first glass and resin microspheres were developed, and first phase 1 trials launched. Since then, transarterial radioembolization (TARE) has been used for the local treatment of primary and metastatic liver disease.
In recent decades,...
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Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 1.Jafargholi Rangraz E, Coudyzer W, Maleux G, Baete K, Deroose CM, Nuyts J. Multi-modal image analysis for semi-automatic segmentation of the total liver and liver arterial perfusion territories for radioembolization. EJNMMI Res. 2019;9(1).Google Scholar
- 3.Saini A, Wallace A, Alzubaidi S, Knuttinen MG, Naidu S, Sheth R, et al. History and evolution of Yttrium-90 radioembolization for hepatocellular carcinoma. J Clin Med. 2019;8(1).Google Scholar