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18F-Flurodeoxyglucose positron emission tomography with computed tomography (FDG PET/CT) findings in children with encephalitis and comparison to conventional imaging

  • Sophie TurpinEmail author
  • Patrick Martineau
  • Marc-André Levasseur
  • Inge Meijer
  • Jean-Claude Décarie
  • Julie Barsalou
  • Christian Renaud
  • Hélène Decaluwe
  • Elie Haddad
  • Raymond Lambert
Original Article
  • 52 Downloads

Abstract

Purpose

FDG PET/CT is emerging as a new tool for the evaluation of acute encephalitis (AE). However, to date, there are no exclusively pediatric studies on the use of FDG PET for suspected AE. The objective of this study was to compare qualitative and quantitative brain PET to conventional brain imaging in a cohort of children, and to identify patterns of metabolic abnormalities characteristic of AE.

Methods

This retrospective study included 34 children imaged with PET/CT, CT and magnetic resonance imaging (MRI). The positivity rate of all three imaging modalities was measured. Besides visual assessment, quantification of relative regional brain metabolism (RRBM) was performed and compared to a database of normal pediatric brains.

Results

Fourteen subjects had a clinical diagnosis of autoimmune encephalitis (AIE) or encephalitis of unknown origin (EX), six of anti-N-methyl-D-aspartate receptor (anti-NMDAr) encephalitis, three of Hashimoto’s encephalopathy, three of neurolupus and eight had other subtypes of encephalitis.

Quantitative PET was abnormal in 100% of cases, visually assessed PET in 94.1% of subjects, MRI in 41.2% and CT in 6.9%. RRBM quantification demonstrated multiple hyper and hypo metabolic cortical regions in 82.3% of subjects, exclusively hypermetabolic abnormalities in 3%, and exclusively hypometabolic abnormalities in 14.7%. The basal ganglia were hypermetabolic in 26.5% of cases on visual assessment and in 58.8% of subjects using quantification.

Conclusion

In our pediatric population FDG PET was more sensitive than conventional imaging for the detection of AE, and basal ganglia hypermetabolism was frequently encountered.

Keywords

Fluorodeoxyglucose Positron emission tomography Computed tomography Magnetic resonance imaging Children Encephalitis 

Notes

Acknowledgements

Dr. Daniel H Silverman, UCLA Medical Center.

Funding

This study was funded from a financial support from the Radiology, Radio-oncology and Nuclear Medicine Department, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada, “10th Faculty Competition”, 2016.

Compliance with ethical standards

Ethical approval

The study was approved by the ethical committee of our institution.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Sophie Turpin
    • 1
    Email author
  • Patrick Martineau
    • 2
  • Marc-André Levasseur
    • 3
  • Inge Meijer
    • 4
  • Jean-Claude Décarie
    • 5
  • Julie Barsalou
    • 6
  • Christian Renaud
    • 7
  • Hélène Decaluwe
    • 6
  • Elie Haddad
    • 6
  • Raymond Lambert
    • 1
  1. 1.Division of Nuclear Medicine, Department of Medical ImagingCentre Hospitalier Universitaire Sainte-JustineMontréalCanada
  2. 2.Department of Nuclear Medicine, Health Sciences CentreUniversity of ManitobaWinnipegCanada
  3. 3.Department of Nuclear MedicineCentre Hospitalier Universitaire de SherbrookeSherbrookeCanada
  4. 4.Division of Neurology, Department of PediatricsCentre Hospitalier Universitaire Sainte-JustineMontréalCanada
  5. 5.Department of Medical ImagingCentre Hospitalier Universitaire Sainte-JustineMontréalCanada
  6. 6.Division of Immunology, Allergy, Rhumatology, Department of PediatricsCentre Hospitalier Universitaire Sainte-JustineMontréalCanada
  7. 7.Division of Microbiology, Infectious Disease, Department of PediatricsCentre Hospitalier Universitaire Sainte-JustineMontréalCanada

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