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Severe posterior hypometabolism but normal perfusion in a patient with chronic fatigue syndrome/myalgic encephalomyelitis revealed by PET/MRI

  • S. SahbaiEmail author
  • P. Kauv
  • M. Abrivard
  • P. Blanc-Durand
  • M. Aoun-Sebati
  • B. Emsen
  • A. Luciani
  • J. Hodel
  • F-J. Authier
  • E. Itti
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Notes

Author’s contribution

SS and EI devised the rationale and designed the original article.

SS and EI wrote the original manuscript and collected the data.

EI, AL and JH supervised the study.

SS, PK and EI analyzed and interpreted the data.

MAS, MA and FJA collected the clinical information and the biopsy results.

SS, EI, PK, PBD and BE participated in manuscript writing, editing, and revision.

All authors have read and approved the final version of the present manuscript.

Funding

This study was not funded by any official grants.

Compliance with ethical standards

Conflicts of interest

All the authors declare that they have no conflict or potential conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the principles of the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the patient for the anonymous use of patient clinical, imaging, and histologic data. This study was approved by the Institutional Review Board (Comité de Protectiondes Personnes Ile-de-France VI, Hôpital Pitié-Salpêtrière,Paris, France).

References

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    Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International chronic fatigue syndrome study group. Ann Intern Med. 1994;121:953–9.CrossRefGoogle Scholar
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    Siessmeier T, Nix WA, Hardt J, Schreckenberger M, Egle UT, Bartenstein P. Observer independent analysis of cerebral glucose metabolism in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry. 2003;74:922–8.CrossRefGoogle Scholar
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    Van Der Gucht A, Aoun Sebaiti M, Guedj E, Aouizerate J, Yara S, Gherardi RK, et al. Brain FDG-PET metabolic abnormalities in patients with long-lasting macrophagic myofasciitis. J Nucl Med. 2017;58:492–8.CrossRefGoogle Scholar
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    Mielke R, Pietrzyk U, Jacobs A, Fink GR, Ichimiya A, Kessler J, et al. HMPAO SPET and FDG PET in Alzheimer's disease and vascular dementia: comparison of perfusion and metabolic pattern. Eur J Nucl Med. 1994;21:1052–60.CrossRefGoogle Scholar
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    Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, et al. Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an (11)C-(R)-PK11195 PET study. J Nucl Med. 2014;55(6):945–50.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • S. Sahbai
    • 1
    Email author
  • P. Kauv
    • 2
  • M. Abrivard
    • 3
  • P. Blanc-Durand
    • 1
  • M. Aoun-Sebati
    • 3
  • B. Emsen
    • 1
  • A. Luciani
    • 4
  • J. Hodel
    • 2
    • 4
  • F-J. Authier
    • 3
  • E. Itti
    • 1
  1. 1.SyMPTOm PET/MRI Platform, Nuclear Medicine DepartmentHenri Mondor University HospitalCréteilFrance
  2. 2.Neuroradiology DepartmentHenri Mondor University HospitalCréteilFrance
  3. 3.INSERM/UPEC U955 Team 10, Faculty of Medicine, 94000 Créteil, France; Expert Center for Neuromuscular Diseases, Department of PathologyHenri Mondor University HospitalCréteilFrance
  4. 4.SyMPTOm PET/MRI Platform, Radiology DepartmentHenri Mondor University HospitalCréteilFrance

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