Treatment of aggressive recurrent meningiomas: spinning towards peptide receptor radionuclide therapy

  • Eric GuedjEmail author
  • Thomas Graillon
  • Olivier Chinot
  • David Taieb
Letter to the Editor


With a worldwide incidence of 45,000 cases, meningioma is the most common nonglial primary intracranial tumour. Although the tumour is often associated with indolent behaviour, in many patients it shows aggressive features and is associated with poor outcomes. After complete resection, the 5-year recurrence rates for grade I (benign), grade II (atypical) and grade III (anaplastic) tumours have been estimated to be 5%, 40% and 80%, respectively [1, 2]. Very few treatment options are available at this stage. The progression-free survival (PFS) in patients with aggressive recurrent meningiomas is less than 30% at 6 months, while the median overall survival is 3 years in patients with grade III tumour [3]. It is therefore of major importance to develop new treatment options.

In recent years, peptide receptor radionuclide therapy (PRRT) with somatostatin analogues (SSAs) has become increasingly important in the treatment of patients with tumours expressing somatostatin receptor (SST),...



This work was conducted in the framework of DHU-Imaging thanks to the support of the A*MIDEX project (no. ANR-11-IDEX-0001-02) (Investissements d’Avenir French Government programme, managed by the French National Research Agency, ANR).

Compliance with ethical standards

Conflicts of interest


Ethical approval

This article does not describe any studies with human participants performed by any of the authors.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Service de Médecine Nucléaire, CHU Timone, Assistance Publique-Hôpitaux de MarseilleMarseilleFrance
  2. 2.CNRS, Ecole Centrale Marseille, UMR 7249, Institut FresnelAix-Marseille UniversitéMarseilleFrance
  3. 3.CERIMEDAix-Marseille UniversitéMarseilleFrance
  4. 4.Service de Neurochirurgie, CHU Timone, Assistance Publique-Hôpitaux de MarseilleMarseilleFrance
  5. 5.CNRS, UMR7286, CRN2MAix-Marseille UniversitéMarseilleFrance
  6. 6.Service de Neuro-Oncologie, CHU Timone, Assistance Publique-Hôpitaux de MarseilleMarseilleFrance
  7. 7.Inserm, U1068-CNRS 7258, Cancer Research Center of MarseilleAix-Marseille UniversitéMarseilleFrance

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