Performance of 18F-FDG PET/MRI and 18F-FDG PET/CT for T and N staging in patients with non-small-cell lung cancer

  • Eric LaffonEmail author
  • Roger Marthan
Letter to the Editor


We read with great interest the recent article by Kirchner and colleagues who compared the performance of 18F-FDG PET/CT and 18F-FDG PET/MRI for primary (T) and locoregional lymph node (N) staging in patients with non-small-cell lung cancer (NSCLC) [1]. 18F-FDG PET/CT and 18F-FDG PET/MRI were successively performed at 60 min and 120 ± 16 min after tracer injection, respectively. T and N stages were determined according to the seventh edition of the American Joint Committee on Cancer staging manual [2]. Quantitative agreement between the two methods in terms of the maximum standardized uptake values (SUVmax) and the sizes of the primary tumours was assessed using Bland-Altman plots. The authors concluded that 18F-FDG PET/MRI and 18F-FDG PET/CT show equivalently high performance for T and N staging in patients with NSCLC. However, they recommended that the quantitative assessment of treatment response should be performed on the same equipment (either PET/MRI or PET/CT) to provide...


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  1. 1.
    Kirchner J, Sawicki LM, Nensa F, Schaarschmidt BM, Reis H, Ingenwerth M, et al. Prospective comparison of 18F-FDG PET/MRI and 18F-FDG PET/CT for thoracic staging of non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2018.
  2. 2.
    Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17:1471–4.CrossRefGoogle Scholar
  3. 3.
    Laffon E, Calcagni ML, Galli G, Giordano A, Capotosti A, Marthan R, et al. Comparison of three-parameter kinetic model analysis to standard Patlak's analysis in 18F-FDG PET imaging of lung cancer patients. EJNMMI Res. 2018;8:24–32.CrossRefGoogle Scholar
  4. 4.
    Dournes G, Grodzki D, Macey J, Girodet PO, Fayon M, Chateil JF, et al. Quiet submillimeter MR imaging of the lung is feasible with a PETRA sequence at 1.5 T. Radiology. 2015;276:258–65.CrossRefGoogle Scholar

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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.CHU de BordeauxBordeauxFrance
  2. 2.Centre de Recherche Cardio-Thoracique de BordeauxUniversity BordeauxBordeauxFrance
  3. 3.INSERM U-1045, Centre de Recherche Cardio-Thoracique de BordeauxBordeauxFrance
  4. 4.Service de Médecine NucléaireHôpital du Haut-LévèquePessacFrance

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