18F-FDG PET/CT imaging factors that predict ischaemic stroke in cancer patients

  • Jahae Kim
  • Kang-Ho ChoiEmail author
  • Ho-Chun Song
  • Joon-Tae Kim
  • Man-Seok Park
  • Ki-Hyun Cho
Original Article



18F-FDG PET/CT can acquire both anatomical and functional images in a single session. We investigated which factors of 18F-FDG PET/CT imaging have potential as biomarkers for an increased risk of ischaemic stroke in cancer patients.


From among cancer patients presenting with various neurological symptoms and hemiparesis, 134 were selected as eligible for this retrospective analysis. A new infarct lesion on brain MRI within 1 year of FDG PET/CT defined future ischaemic stroke. The target-to-background ratio (TBR) of each arterial segment was used to define arterial inflammation on PET imaging. Abdominal obesity was defined in terms of the area and proportion of visceral adipose tissue (VAT), subcutaneous adipose tissue and total adipose tissue (TAT) on a single CT slice at the umbilical level.


Ischaemic stroke confirmed by MRI occurred in 30 patients. Patients with stroke had higher TBRs in the carotid arteries and abdominal aorta (P < 0.001) and a higher VAT proportion (P = 0.021) and TAT proportion (P = 0.041) than patients without stroke. Multiple logistic regression analysis showed that TBRs of the carotid arteries and abdominal aorta, VAT and TAT proportions, and the presence of a metabolically active tumour were significantly associated with future ischaemic stroke. Combining PET and CT variables improved the power for predicting future ischaemic stroke.


Our findings suggest that arterial FDG uptake and hypermetabolic malignancy on PET and the VAT proportion on CT could be independent predictors of future ischaemic stroke in patients with cancer and could identify those patients who would benefit from medical treatment.


Stroke Adipose tissue PET/CT Cancer Predictor 


Compliance with ethical standards


This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI12C1631, Choi K.H.).

Conflicts of interest


Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the principles of the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Jahae Kim
    • 1
  • Kang-Ho Choi
    • 2
    • 3
    Email author
  • Ho-Chun Song
    • 1
  • Joon-Tae Kim
    • 2
  • Man-Seok Park
    • 2
  • Ki-Hyun Cho
    • 2
  1. 1.Department of Nuclear MedicineChonnam National University HospitalGwangjuKorea
  2. 2.Cerebrovascular CenterChonnam National University HospitalGwangjuKorea
  3. 3.Department of NeurologyChonnam National University Hwasun HospitalHwasun-gunRepublic of Korea

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