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FDG-PET/ceCT is useful to predict recurrence of Pseudomyxoma peritonei

  • Julien DubreuilEmail author
  • Francesco Giammarile
  • Pascal Rousset
  • Naoual Bakrin
  • Guillaume Passot
  • Sylvie Isaac
  • Olivier Glehen
  • Andrea Skanjeti
Original Article

Abstract

Purpose

Pseudomyxoma peritonei (PMP) is a rare peritoneal neoplasm originating from appendicular tumours. There is no consolidated data available in the literature about the precise role of [18F] fluorodesoxy-D-glucose Positron Emission Tomography / contrast enhanced Computed Tomography (FDG-PET/ceCT). The aim of this study was to evaluate the correlation between preoperative FDG-PET/ceCT (qualitative and semi-quantitative assessment) and progression free survival (PFS) of patients treated for PMP.

Methods

All patients scheduled for PMP treatment by cytoreductive unicentric surgery, intraperitoneal chemotherapy (HIPEC), and who underwent a FDG-PET/ceCT between February 2008 and January 2014, were included. No previous treatment was performed (except biopsy or appendectomy). FDG-PET/ceCT was interpreted by two nuclear physicians in consensus. Positive FDG-PET/ceCT scans were further labelled in diffuse disease and poly/mono focal disease. SUVmax was measured based on post-operative reports. The Peritoneal Cancer Index (PCI) and Completeness of CytoReduction Score (CCR) were assessed after surgery.

Results

Fifty-six patients were included in this study, with a mean age of 56-years-old and a mean follow-up of 29.3 months. SUVmax, with a cut-off at 2.02, was predictive for the PFS on multivariate analysis. No differences were observed between diffuse disease and focal disease on PFS for progression free survival, PCI, and SUVmax (p = 0.1). Post-operative CCR was not significantly correlated with SUVmax or FDG-PET/ceCT qualitative assessment.

Conclusion

SUVmax on preoperative FDG-PET/ceCT was an independent predictive factor for PFS in PMP. Further studies are needed to explore if FDG-PET/ceCT could potentially predict post-operative CCR.

Keywords

Pseudomyxoma peritonei FDG-PET/ceCT Recurrence Prognosis Intraperitoneal chemotherapy 

Notes

Acknowledgments

The authors gratefully acknowledge the assistance of Isabelle Bonnefoy on data collection and of Eda Koxhaku on English editing.

Compliance with ethical standards

Conflicts of interest

None

Funding

None

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Julien Dubreuil
    • 1
    • 2
    Email author
  • Francesco Giammarile
    • 3
    • 4
  • Pascal Rousset
    • 2
    • 5
  • Naoual Bakrin
    • 6
  • Guillaume Passot
    • 7
  • Sylvie Isaac
    • 8
  • Olivier Glehen
    • 2
    • 7
    • 9
  • Andrea Skanjeti
    • 1
    • 2
  1. 1.Nuclear Medicine and PET UnitCentre Hospitalier Lyon-Sud, Hospices Civils de LyonPierre-BéniteFrance
  2. 2.Equipe Mixte de Recherche 3738Université Claude Bernard Lyon 1LyonFrance
  3. 3.Nuclear Medicine DepartmentGroupement Hospitalier EstBronFrance
  4. 4.Biophysique - Faculté Charles Mérieux LyonLyonFrance
  5. 5.Radiology DepartmentCentre Hospitalier Lyon-Sud, Hospices Civils de LyonPierre-BéniteFrance
  6. 6.Gynaecology DepartmentGroupement Hospitalier Est, Hospices Civils de LyonBronFrance
  7. 7.General and oncologic surgery DepartmentCentre Hospitalier Lyon-Sud, Hospices Civils de LyonPierre-BéniteFrance
  8. 8.Pathology DepartmentCentre Hospitalier Lyon-Sud, Hospices Civils de LyonPierre-BéniteFrance
  9. 9.Lyon 1 UniversityVilleurbanneFrance

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