Visual and statistical analysis of 18F-FDG PET in primary progressive aphasia

  • Jordi A. Matías-GuiuEmail author
  • María Nieves Cabrera-Martín
  • María Jesús Pérez-Castejón
  • Teresa Moreno-Ramos
  • Cristina Rodríguez-Rey
  • Rocío García-Ramos
  • Aida Ortega-Candil
  • Marta Fernandez-Matarrubia
  • Celia Oreja-Guevara
  • Jorge Matías-Guiu
  • José Luis Carreras
Original Article



Diagnosing progressive primary aphasia (PPA) and its variants is of great clinical importance, and fluorodeoxyglucose (FDG) positron emission tomography (PET) may be a useful diagnostic technique. The purpose of this study was to evaluate interobserver variability in the interpretation of FDG PET images in PPA as well as the diagnostic sensitivity and specificity of the technique. We also aimed to compare visual and statistical analyses of these images.


There were 10 raters who analysed 44 FDG PET scans from 33 PPA patients and 11 controls. Five raters analysed the images visually, while the other five used maps created using Statistical Parametric Mapping software. Two spatial normalization procedures were performed: global mean normalization and cerebellar normalization. Clinical diagnosis was considered the gold standard.


Inter-rater concordance was moderate for visual analysis (Fleiss’ kappa 0.568) and substantial for statistical analysis (kappa 0.756–0.881). Agreement was good for all three variants of PPA except for the nonfluent/agrammatic variant studied with visual analysis. The sensitivity and specificity of each rater’s diagnosis of PPA was high, averaging 87.8 and 89.9 % for visual analysis and 96.9 and 90.9 % for statistical analysis using global mean normalization, respectively. In cerebellar normalization, sensitivity was 88.9 % and specificity 100 %.


FDG PET demonstrated high diagnostic accuracy for the diagnosis of PPA and its variants. Inter-rater concordance was higher for statistical analysis, especially for the nonfluent/agrammatic variant. These data support the use of FDG PET to evaluate patients with PPA and show that statistical analysis methods are particularly useful for identifying the nonfluent/agrammatic variant of PPA.


18F-FDG PET Brain imaging Primary progressive aphasia Statistical Parametric Mapping 


Compliance with ethical standards

All procedures performed involving human participants were in accordance with the ethical standards of the Institutional Research Committee and with the 1964 Helsinki Declaration and its later amendments.

Conflicts of interest


Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

259_2015_2994_MOESM1_ESM.docx (92 kb)
ESM 1 (DOCX 92 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jordi A. Matías-Guiu
    • 1
    Email author
  • María Nieves Cabrera-Martín
    • 2
  • María Jesús Pérez-Castejón
    • 2
  • Teresa Moreno-Ramos
    • 1
  • Cristina Rodríguez-Rey
    • 2
  • Rocío García-Ramos
    • 1
  • Aida Ortega-Candil
    • 2
  • Marta Fernandez-Matarrubia
    • 1
  • Celia Oreja-Guevara
    • 1
  • Jorge Matías-Guiu
    • 1
  • José Luis Carreras
    • 2
  1. 1.Department of NeurologyHospital Clínico San CarlosMadridSpain
  2. 2.Department of Nuclear Medicine, Hospital Clínico San CarlosSan Carlos Health Research Institute (IdISSC) Complutense University of MadridMadridSpain

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