Imaging biomarkers in prostate cancer: role of PET/CT and MRI

  • M. Picchio
  • P. Mapelli
  • V. Panebianco
  • P. Castellucci
  • E. Incerti
  • A. Briganti
  • G. Gandaglia
  • M. Kirienko
  • F. Barchetti
  • C. Nanni
  • F. Montorsi
  • L. Gianolli
  • S. Fanti
Review Article


Prostate-specific antigen (PSA) is currently the most widely used biomarker of prostate cancer (PCa). PSA suggests the presence of primary tumour and disease relapse after treatment, but it is not able to provide a clear distinction between locoregional and distant disease. Molecular and functional imaging, that are able to provide a detailed and comprehensive overview of PCa extension, are more reliable tools for primary tumour detection and disease extension assessment both in staging and restaging. In the present review we evaluate the role of PET/CT and MRI in the diagnosis, staging and restaging of PCa, and the use of these imaging modalities in prognosis, treatment planning and response assessment. Innovative imaging strategies including new radiotracers and hybrid scanners such as PET/MRI are also discussed.


Prostate cancer Biomarker Imaging PET/CT MRI 


Conflicts of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • M. Picchio
    • 1
  • P. Mapelli
    • 1
  • V. Panebianco
    • 2
  • P. Castellucci
    • 3
  • E. Incerti
    • 1
  • A. Briganti
    • 4
  • G. Gandaglia
    • 4
  • M. Kirienko
    • 5
  • F. Barchetti
    • 2
  • C. Nanni
    • 3
  • F. Montorsi
    • 4
  • L. Gianolli
    • 1
  • S. Fanti
    • 3
  1. 1.Nuclear Medicine UnitIRCCS San Raffaele Scientific InstituteMilanItaly
  2. 2.Department of Radiological Sciences, Oncology and PathologySapienza UniversityRomeItaly
  3. 3.Nuclear Medicine UnitPoliclinico S. Orsola Malpighi - University of BolognaBolognaItaly
  4. 4.Urological Research Institute, IRCCS San Raffaele Scientific InstituteMilanItaly
  5. 5.University of Milano-BicoccaMilanItaly

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