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Assessment of aortitis by semiquantitative analysis of 180-min 18F-FDG PET/CT acquisition images

  • Isabel Martínez-RodríguezEmail author
  • N. Martínez-Amador
  • I. Banzo
  • R. Quirce
  • J. Jiménez-Bonilla
  • M. De Arcocha-Torres
  • S. Ibáñez-Bravo
  • C. Lavado-Pérez
  • Z. Bravo-Ferrer
  • R. Blanco
  • M. A. González-Gay
  • J. M. Carril
Original Article

Abstract

Purpose

The aim of this study was to evaluate the contribution of semiquantitative analysis of 180-min 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images for the assessment of aortitis in cases of suspected large vessel vasculitis (LVV) and to establish a threshold index for application in the clinical setting.

Methods

This prospective study included 43 patients (mean age 67.5 ± 12.9 years) with suspicion of LVV (25 with a final diagnosis of aortitis). 18F-FDG PET/CT scan was acquired 180 min after injection of 7 MBq/kg of 18F-FDG. A semiquantitative analysis was performed calculating the aortic wall maximum standardized uptake value (SUVmax) (T), the lumen SUVmax (B) and the target to background ratio (TBR). These results were also compared with those obtained in a control population.

Results

The mean aortic wall SUVmax was 2.00 ± 0.62 for patients with aortitis and 1.45 ± 0.31 for patients without aortitis (p < 0.0001). The TBR was 1.66 ± 0.26 for patients with aortitis and 1.24 ± 0.08 for patients without aortitis (p < 0.0001). The differences were also statistically significant when the patients with aortitis and controls were compared. Receiver-operating characteristic (ROC) analysis revealed that the area under the curve was greater for the TBR than for the aortic wall SUVmax (0.997 vs 0.871). The highest sensitivity and specificity was obtained for a TBR of 1.34 (sensitivity 100 %, specificity 94.4 %).

Conclusion

Semiquantitative analysis of PET/CT images acquired 180 min after 18F-FDG injection and the TBR index of 1.34 show very high accuracy and, therefore, are strongly recommended for the diagnosis of aortitis in the clinical setting.

Keywords

Aortitis Large vessel vasculitis Giant cell arteritis 18F-FDG PET/CT Positron emission tomography 

Notes

Conflicts of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Isabel Martínez-Rodríguez
    • 1
    • 3
    Email author
  • N. Martínez-Amador
    • 1
  • I. Banzo
    • 1
  • R. Quirce
    • 1
  • J. Jiménez-Bonilla
    • 1
  • M. De Arcocha-Torres
    • 1
  • S. Ibáñez-Bravo
    • 1
  • C. Lavado-Pérez
    • 1
  • Z. Bravo-Ferrer
    • 1
  • R. Blanco
    • 2
  • M. A. González-Gay
    • 2
  • J. M. Carril
    • 1
  1. 1.Department of Nuclear Medicine, Marqués de Valdecilla University HospitalUniversity of CantabriaSantanderSpain
  2. 2.Department of Rheumatology, Marqués de Valdecilla University HospitalUniversity of CantabriaSantanderSpain
  3. 3.S. Medicina NuclearHospital Universitario Marqués de ValdecillaSantanderSpain

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