Image acquisition and interpretation criteria for 99mTc-HMPAO-labelled white blood cell scintigraphy: results of a multicentre study

  • Paola A. Erba
  • Andor W. J. M. Glaudemans
  • Niels C. Veltman
  • Martina Sollini
  • Marta Pacilio
  • Filippo Galli
  • Rudi A. J. O. Dierckx
  • Alberto Signore
Original Article

Abstract

Purpose

There is no consensus yet on the best protocol for planar image acquisition and interpretation of radiolabelled white blood cell (WBC) scintigraphy. This may account for differences in reported diagnostic accuracy amongst different centres.

Methods

This was a multicentre retrospective study analysing 235 WBC scans divided into two groups. The first group of scans (105 patients) were acquired with a fixed-time acquisition protocol and the second group (130 patients) were acquired with a decay time-corrected acquisition protocol. Planar images were interpreted both qualitatively and semiquantitatively. Three blinded readers analysed the images.

Results

The most accurate imaging acquisition protocol comprised image acquisition at 3 – 4 h and at 20 – 24 h in time mode with acquisition times corrected for isotope decay.

Conclusion

Using this protocol, visual analysis had high sensitivity and specificity in the diagnosis of infection. Semiquantitative analysis could be used in doubtful cases, with no cut-off for the percentage increase in radiolabelled WBC over time, as a criterion to define a positive scan.

Keywords

White blood cells Scintigraphy Infection imaging 

Notes

Conflicts of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Paola A. Erba
    • 1
  • Andor W. J. M. Glaudemans
    • 2
  • Niels C. Veltman
    • 3
  • Martina Sollini
    • 4
  • Marta Pacilio
    • 5
  • Filippo Galli
    • 5
  • Rudi A. J. O. Dierckx
    • 2
  • Alberto Signore
    • 2
    • 5
    • 6
  1. 1.Regional Center of Nuclear Medicine, Department of Translational Research and Advanced Technologies in MedicineUniversity of Pisa Medical SchoolPisaItaly
  2. 2.Department of Nuclear Medicine and Molecular Imaging, University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands
  3. 3.Department of Nuclear MedicineJeroen Bosch Hospital‘s-HertogenboschThe Netherlands
  4. 4.Nuclear Medicine Unit, Department of Oncology and Advanced TechnologyArcispedale S. Maria Nuova – IRCCSReggio EmiliaItaly
  5. 5.Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology“Sapienza” UniversityRomeItaly
  6. 6.Medicina Nucleare, Ospedale S. AndreaUniversity of Rome “Sapienza”RomaItaly

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