The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis

  • Claudia Calcagno
  • Sarayu Ramachandran
  • David Izquierdo-Garcia
  • Venkatesh Mani
  • Antoine Millon
  • David Rosenbaum
  • Ahmed Tawakol
  • Mark Woodward
  • Jan Bucerius
  • Erin Moshier
  • James Godbold
  • David Kallend
  • Michael E. Farkouh
  • Valentin Fuster
  • James H. F. Rudd
  • Zahi A. Fayad
Original Article

Abstract

Purpose

Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. We studied the relationship between DCE-MRI and 18F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473).

Methods

The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18F-FDG PET. Only baseline imaging and biomarker data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18F-FDG PET data. As secondary endpoints, we evaluated the relationship between (a) PET data and whole-vessel anatomical MRI data, and (b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model.

Results

We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI and DCE-MRI or 18F-FDG PET metrics.

Conclusion

In this study we observed a significant, weak inverse relationship between inflammation measured as 18F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18F-FDG PET and DCE-MRI may have complementary roles in future clinical practice in identifying subjects at high risk of cardiovascular events.

Keywords

DCE-MRI PET/CT Atherosclerosis Inflammation Neovascularization 

Notes

Acknowledgments

F. Hoffmann-La Roche Ltd funded the dal-PLAQUE study and provided third-party editorial support, through Prime Healthcare Ltd, for the preparation of the manuscript. C.C. acknowledges grant and research support from the National Institutes of Health and National Heart Lung and Blood Institute (NIH/NHLBI R01 HL071021, NIH/NHLBI R01 HL078667 and NIH/NCRR UL1RR029887).

Conflicts of interest

S.R., D.I.-G., A.M., D.R., J.B., E.M., J.G. and V.F. indicate that they have nothing to disclose. VM discloses that he receives consulting fees from Tursiop Inc. A.T. discloses that he has received honoraria from Roche, BMS and Novartis, and research grants from Merck, BMS, Genentech, GSK and VBL. M.W. discloses that he has received honoraria from Roche. D.K. is an employee of F. Hoffmann-La Roche Ltd. M.E.F. discloses that he has received honoraria from Roche and acted as a consultant to Genentech. J.H.F.R. discloses that he has received honoraria from Roche and is part-supported by the National Institute for Health Research Cambridge Biomedical Research Centre. Z.A.F. discloses that he has received research grants from Roche, GlaxoSmithKline, Merck, VBL Therapeutics, Novartis, Bristol-Myers Squibb, and Via Pharmaceuticals, and honoraria from Roche.

Supplementary material

259_2013_2518_MOESM1_ESM.docx (23 kb)
ESM 1(DOCX 23 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Claudia Calcagno
    • 1
    • 2
  • Sarayu Ramachandran
    • 1
    • 2
  • David Izquierdo-Garcia
    • 3
  • Venkatesh Mani
    • 1
    • 2
  • Antoine Millon
    • 1
    • 2
  • David Rosenbaum
    • 4
  • Ahmed Tawakol
    • 5
  • Mark Woodward
    • 6
  • Jan Bucerius
    • 7
    • 8
    • 9
  • Erin Moshier
    • 10
  • James Godbold
    • 10
  • David Kallend
    • 11
  • Michael E. Farkouh
    • 12
    • 13
  • Valentin Fuster
    • 12
    • 14
  • James H. F. Rudd
    • 15
  • Zahi A. Fayad
    • 1
    • 2
    • 12
  1. 1.Translational and Molecular Imaging InstituteMount Sinai School of MedicineNew YorkUSA
  2. 2.Department of RadiologyMount Sinai School of MedicineNew YorkUSA
  3. 3.Athinoula A. Martinos Center for Biomedical ImagingHarvard University - MIT - Massachusetts General HospitalCharlestownUSA
  4. 4.Hopital Pitié SalpétrièreParisFrance
  5. 5.Harvard Medical School and Massachusetts General HospitalBostonUSA
  6. 6.George InstituteUniversity of SydneySydneyAustralia
  7. 7.Department of Nuclear MedicineMaastricht University Medical CenterMaastrichtThe Netherlands
  8. 8.Cardiovascular Research Institute Maastricht (CARIM)MaastrichtThe Netherlands
  9. 9.Department of Nuclear MedicineRheinisch-Westfaelische Technische Hochschule AachenAachenGermany
  10. 10.Biostatistics Shared Research FacilityMount Sinai School of MedicineNew YorkUSA
  11. 11.F. Hoffmann-La Roche LtdBaselSwitzerland
  12. 12.Cardiovascular InstituteMount Sinai School of MedicineNew YorkUSA
  13. 13.Peter Munk Cardiac Centre and Li Ka Shing Knowledge InstituteTorontoCanada
  14. 14.The Centro Nacional de Investigaciones Cardiovasculares (CNIC)MadridSpain
  15. 15.Division of Cardiovascular MedicineUniversity of CambridgeCambridgeUK

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