Optical imaging as an expansion of nuclear medicine: Cerenkov-based luminescence vs fluorescence-based luminescence

  • Patrick T. K. Chin
  • Mick M. Welling
  • Stefan C. J. Meskers
  • Renato A. Valdes Olmos
  • Hans Tanke
  • Fijs W. B. van Leeuwen
Review Article


Integration of optical imaging technologies can further strengthen the field of radioguided surgery. Rather than using two separate chemical entities to achieve this extension, hybrid imaging agents can be used that contain both radionuclear and optical properties. Two types of such hybrid imaging agents are available: (1) hybrid imaging agents generated by Cerenkov luminescence imaging (CLI) of β-emitters and (2) hybrid imaging agents that contain both a radioactive moiety and a fluorescent dye. One major challenge clinicians are now facing is to determine the potential value of these approaches. With this tutorial review we intend to clarify the differences between the two approaches and highlight the clinical potential of hybrid imaging during image-guided surgery applications.


Cerenkov Fluorescence Multimodal imaging Image-guided surgery Nuclear medicine 



This work was financially supported by the division of Chemical Sciences (CW) of the Dutch Science Foundation (NWO) under grant number VENI 722.011.005 (PC) and NWO-STW-VIDI (Grant No. STW BGT11271; FvL).

Conflicts of interest


Supplementary material

259_2013_2408_MOESM1_ESM.doc (89 kb)
ESM 1 (DOC 89.0 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Patrick T. K. Chin
    • 1
  • Mick M. Welling
    • 1
  • Stefan C. J. Meskers
    • 2
  • Renato A. Valdes Olmos
    • 1
    • 3
  • Hans Tanke
    • 4
  • Fijs W. B. van Leeuwen
    • 1
  1. 1.Interventional Molecular Imaging Laboratory, Department of RadiologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Molecular Materials and NanosystemsEindhoven University of TechnologyEindhovenThe Netherlands
  3. 3.Department of Nuclear MedicineNetherlands Cancer Institute-Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands
  4. 4.Department of Molecular Cell BiologyLeiden University Medical CenterLeidenThe Netherlands

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