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Comparison of 18F-FACBC and 11C-choline PET/CT in patients with radically treated prostate cancer and biochemical relapse: preliminary results

  • Cristina Nanni
  • Riccardo Schiavina
  • Stefano Boschi
  • Valentina Ambrosini
  • Cinzia Pettinato
  • Eugenio Brunocilla
  • Giuseppe Martorana
  • Stefano Fanti
Original Article

Abstract

Purpose

We assessed the rate of detection rate of recurrent prostate cancer by PET/CT using anti-3-18F-FACBC, a new synthetic amino acid, in comparison to that using 11C-choline as part of an ongoing prospective single-centre study.

Methods

Included in the study were 15 patients with biochemical relapse after initial radical treatment of prostate cancer. All the patients underwent anti-3-18F-FACBC PET/CT and 11C-choline PET/CT within a 7-day period. The detection rates using the two compounds were determined and the target–to-background ratios (TBR) of each lesion are reported.

Results

No adverse reactions to anti-3-18F-FACBC PET/CT were noted. On a patient basis, 11C-choline PET/CT was positive in 3 patients and negative in 12 (detection rate 20 %), and anti-3-18F-FACBC PET/CT was positive in 6 patients and negative in 9 (detection rate 40 %). On a lesion basis, 11C-choline detected 6 lesions (4 bone, 1 lymph node, 1 local relapse), and anti-3-18F-FACBC detected 11 lesions (5 bone, 5 lymph node, 1 local relapse). All 11C-choline-positive lesions were also identified by anti-3-18F-FACBC PET/CT. The TBR of anti-3-18F-FACBC was greater than that of 11C-choline in 8/11 lesions, as were image quality and contrast.

Conclusion

Our preliminary results indicate that anti-3-18F-FACBC may be superior to 11C-choline for the identification of disease recurrence in the setting of biochemical failure. Further studies are required to assess efficacy of anti-3-18F-FACBC in a larger series of prostate cancer patients.

Keywords

ANTI-3-18F-FACBC 11C-Choline PET/CT Prostate cancer PSA 

Notes

Conflicts of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Cristina Nanni
    • 1
  • Riccardo Schiavina
    • 2
  • Stefano Boschi
    • 1
  • Valentina Ambrosini
    • 2
  • Cinzia Pettinato
    • 3
  • Eugenio Brunocilla
    • 2
  • Giuseppe Martorana
    • 2
  • Stefano Fanti
    • 2
  1. 1.OU Nuclear MedicineAzienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-MalpighiBolognaItaly
  2. 2.OU UrologyAzienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-MalpighiBolognaItaly
  3. 3.OU Medical PhysicsAzienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-MalpighiBolognaItaly

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