Dosimetry of 223Ra-chloride: dose to normal organs and tissues
- 1.5k Downloads
223Ra-Chloride (also called Alpharadin®) targets bone metastases with short range alpha particles. In recent years several clinical trials have been carried out showing, in particular, the safety and efficacy of palliation of painful bone metastases in patients with castration-resistant prostate cancer using 223Ra-chloride. The purpose of this work was to provide a comprehensive dosimetric calculation of organ doses after intravenous administration of 223Ra-chloride according to the present International Commission on Radiological Protection (ICRP) model for radium.
Absorbed doses were calculated for 25 organs or tissues.
Bone endosteum and red bone marrow show the highest dose coefficients followed by liver, colon and intestines. After a treatment schedule of six intravenous injections with 0.05 MBq/kg of 223Ra-chloride each, corresponding to 21 MBq for a 70 kg patient, the absorbed alpha dose to the bone endosteal cells is about 16 Gy and the corresponding absorbed dose to the red bone marrow is approximately 1.5 Gy.
The comprehensive list of dose coefficients presented in this work will assist in comparing and evaluating organ doses from various therapy modalities used in nuclear medicine and will provide a base for further development of patient-specific dosimetry.
Keywords223Ra-Chloride Alpharadin® Bone metastases Castration-resistant prostate cancer Dosimetry
Conflicts of interest
- 4.Nilsson S, Strang P, Aksnes AK, Franzèn L, Olivier P, Pecking A, et al. A randomized, dose–response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer. Eur J Cancer 2012;48:678–86.PubMedCrossRefGoogle Scholar
- 5.Lewington V, Lamey R, Staudacher K, Vogelzang N. Radium-223 chloride: radiation safety, tolerability, and survival gain in patients with castration-resistant prostate cancer (CRPC) and bone metastases. J Nucl Med 2012;53(Suppl 1):222.Google Scholar
- 6.ICRP. Publication 67: Age-dependent doses to members of the public from intake of radionuclides: part 2 ingestion dose coefficients. Ann ICRP 1992;22.Google Scholar
- 9.Leggett RW. A generic age-specific biokinetic model for calcium-like elements. Radiat Prot Dosimetry 1992;41:183–98.Google Scholar
- 10.ICRP. Publication 71: Age-dependent doses to members of the public from intake of radionuclides: part 4 inhalation dose coefficients. Ann ICRP 1995;25.Google Scholar
- 11.ICRP. Publication 110: Adult reference computational phantoms. Ann ICRP 2009;2.Google Scholar
- 12.ICRP. Publication 30 (part 1): Limits for intakes of radionuclides by workers. Ann ICRP 1979;2.Google Scholar
- 13.ICRP. Publication 100. Human alimentary tract model for radiological protection. Ann ICRP 2006;36:1–2.Google Scholar
- 16.ICRP. Publication 103: The 2007 recommendations of the International Commission on Radiological Protection. Ann ICRP 2007;2007:37.Google Scholar