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Dosimetry of 223Ra-chloride: dose to normal organs and tissues

  • Michael Lassmann
  • Dietmar Nosske
Original Article

Abstract

Purpose

223Ra-Chloride (also called Alpharadin®) targets bone metastases with short range alpha particles. In recent years several clinical trials have been carried out showing, in particular, the safety and efficacy of palliation of painful bone metastases in patients with castration-resistant prostate cancer using 223Ra-chloride. The purpose of this work was to provide a comprehensive dosimetric calculation of organ doses after intravenous administration of 223Ra-chloride according to the present International Commission on Radiological Protection (ICRP) model for radium.

Methods

Absorbed doses were calculated for 25 organs or tissues.

Results

Bone endosteum and red bone marrow show the highest dose coefficients followed by liver, colon and intestines. After a treatment schedule of six intravenous injections with 0.05 MBq/kg of 223Ra-chloride each, corresponding to 21 MBq for a 70 kg patient, the absorbed alpha dose to the bone endosteal cells is about 16 Gy and the corresponding absorbed dose to the red bone marrow is approximately 1.5 Gy.

Conclusion

The comprehensive list of dose coefficients presented in this work will assist in comparing and evaluating organ doses from various therapy modalities used in nuclear medicine and will provide a base for further development of patient-specific dosimetry.

Keywords

223Ra-Chloride Alpharadin® Bone metastases Castration-resistant prostate cancer Dosimetry 

Notes

Conflicts of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Nuclear MedicineUniversity of WürzburgWürzburgGermany
  2. 2.Department of Radiation and HealthFederal Office for Radiation Protection (BfS)OberschleißheimGermany

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