Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging

  • Chien-Cheng Chen
  • Thau-Yun Shen
  • Ming-Che Chang
  • Guang-Uei HungEmail author
  • Wan-Chen Chen
  • Chia-Hung Kao
  • Ji Chen
Original Article



In 201Tl SPECT myocardial perfusion imaging (MPI) data are acquired shortly after the stress injection to assess early post-stress left ventricle (LV) function. The purpose of this study was to use 201Tl SPECT MPI to investigate whether stress-induced myocardial ischemia is associated with LV mechanical dyssynchrony.


Enrolled in the study were 75 patients who were referred for dipyridamole stress and rest 201Tl gated SPECT MPI. The early post-stress scan was started 5 min after injection, and followed by the rest scan 4 h later. The patients were divided into three groups: ischemia group (N = 25, summed stress score, SSS, ≥5, summed rest score, SRS, <5), infarct group (N = 16, SSS ≥5, SRS ≥5) and normal group (N = 34, SSS <5, SRS <5). LV dyssynchrony parameters were calculated by phase analysis, and compared between the stress and rest images.


In the ischemia group, LV dyssynchrony was significantly larger during stress than during rest. On the contrary, LV dyssynchrony during stress was significantly smaller than during rest in the normal and infarct groups. LV dyssynchrony during rest was significantly larger in the infarct group than in the normal and ischemia groups. There were no significant differences in LV dyssynchrony during rest between the normal and ischemia groups.


Stress-induced myocardial ischemia caused dyssynchronous contraction in the ischemic region, leading to a deterioration in LV synchrony. Normal myocardium had more synchronous contraction during stress. The different dyssynchrony pattern between ischemic and normal myocardium early post-stress may aid the diagnosis of coronary artery disease using 201Tl gated SPECT MPI.


Thallium-201 Gated SPECT Left-ventricular dyssynchrony Myocardial ischemia 



This study was supported in part by a research grant from Show Chwan Memorial Hospital (RD100003) and an NIH grant (1R01HL094438, PI: Ji Chen, PhD).

Conflicts of interest

Dr. Ji Chen receives royalties from the sale of Emory SyncTool. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict-of-interest practice.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Chien-Cheng Chen
    • 1
  • Thau-Yun Shen
    • 1
  • Ming-Che Chang
    • 2
  • Guang-Uei Hung
    • 3
    • 4
    Email author
  • Wan-Chen Chen
    • 3
  • Chia-Hung Kao
    • 4
  • Ji Chen
    • 5
  1. 1.Department of CardiologyShow Chwan Memorial HospitalChanghuaTaiwan
  2. 2.Department of Nuclear MedicineChanghua Christian HospitalChanghuaTaiwan
  3. 3.Department of Nuclear MedicineChang Bing Show Chwan Memorial HospitalChanghuaTaiwan
  4. 4.Department of Biomedical Imaging and Radiological ScienceChina Medical UniversityTaichungTaiwan
  5. 5.Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaUSA

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