Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling

  • Nobuyuki Ohte
  • Hitomi Narita
  • Akihiko Iida
  • Hidekatsu Fukuta
  • Narushi Iizuka
  • Junichiro Hayano
  • Yuji Kuge
  • Nagara Tamaki
  • Genjiro Kimura
Original Article

Abstract

Purpose

After myocardial infarction (MI), left ventricular (LV) remodelling is observed in noninfarcted LV myocardium. LV remodelling is closely associated with systolic heart failure. Since myocardial dysfunction is related to the downregulation of cardiac postsynaptic beta-adrenergic receptors (β-AR), we hypothesized that a reduction in β-AR density may be manifested in the remote noninfarcted region and such reduction may be related to myocardial systolic dysfunction. Accordingly, we assessed β-AR density with a focus on the remote noninfarcted region.

Methods

Cardiac PET was performed in 15 patients with a prior MI and 10 age-matched healthy controls using 11C-CGP 12177, a radioligand for β-receptors. The maximum number of available specific 11C-CGP 12177 binding sites per gram of tissue was calculated in regions of interest using an established graphical method. LV regional systolic function was assessed based on peak systolic myocardial strain on the LV wall in the longitudinal direction using two-dimensional ultrasound speckle tracking imaging. LV volumes and LV ejection fraction (EF) were also measured.

Results

The LV end-diastolic volume index was significantly larger in patients than in controls (67.8 ± 16.9 vs. 49.1 ± 12.3 ml/m2, p < 0.01). Significant differences in β-AR density were observed among three areas: the apical area in controls (where the lowest β-AR density was observed), the remote noninfarcted region of patients and LVEF ≥55 %, and the remote noninfarcted region of patients and LVEF <55 % (5.8 ± 2.1 vs. 4.2 ± 0.7 vs. 3.3 ± 0.7 pmol/ml, p < 0.01, ANOVA). Peak systolic myocardial strain was significantly reduced in the remote noninfarcted LV wall in patients with a prior anterior wall MI compared with that in the corresponding wall in controls (−15.5 ± 2.5 vs. −20.1 ± 2.2 %, p < 0.001). A similar finding was also observed in patients with a prior inferior wall MI.

Conclusion

In the remote noninfarcted region in patients, β-AR downregulation was observed, which was related to deterioration of local myocardial systolic function.

Keywords

β-adrenergic receptor CGP 12177 Left ventricle Myocardial infarction Remodelling 

Notes

Acknowledgments

This work was partly supported by a Grant-in-Aid for Scientific Research (no. 18591359) from the Japan Society for the Promotion of Science.

Conflicts of interest

None.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Nobuyuki Ohte
    • 1
  • Hitomi Narita
    • 2
  • Akihiko Iida
    • 3
  • Hidekatsu Fukuta
    • 1
  • Narushi Iizuka
    • 4
  • Junichiro Hayano
    • 4
  • Yuji Kuge
    • 5
  • Nagara Tamaki
    • 6
  • Genjiro Kimura
    • 1
  1. 1.Department of Cardio-Renal Medicine and HypertensionNagoya City University Graduate School of Medical SciencesNagoyaJapan
  2. 2.Department of Internal MedicineNagoya City Rehabilitation and Sports Center HospitalNagoyaJapan
  3. 3.Department of RadiologyNagoya City Rehabilitation and Sports Center HospitalNagoyaJapan
  4. 4.Department of Medical EducationNagoya City University Graduate School of Medical SciencesNagoyaJapan
  5. 5.Central Institute of Isotope ScienceHokkaido UniversitySapporoJapan
  6. 6.Department of Nuclear MedicineHokkaido University Graduate School of MedicineSapporoJapan

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