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The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers

  • Yen-Wen Wu
  • Hsian-Li Kao
  • Chi-Lun Huang
  • Ming-Fong Chen
  • Lian-Yu Lin
  • Yi-Chih Wang
  • Yen-Hung Lin
  • Hung-Ju Lin
  • Kai-Yuan Tzen
  • Ruoh-Fang Yen
  • Yu-Chiao Chi
  • Por-Jau Huang
  • Wei-Shiung Yang
Original Article

Abstract

Purpose

18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has the potential to track vascular inflammation and monitor therapeutic response. The purpose of this study was to determine the association between arterial inflammation, calcification and serological biomarkers in subjects with atherosclerosis, and to assess their therapeutic response to 12-week atorvastatin treatment.

Methods

Forty-three statin-naïve subjects with atherosclerosis received atorvastatin (40 mg/day) for 12 weeks and underwent 18F-FDG PET/CT, coronary calcification and abdominal adipose tissue volume measurements. A panel of serological biomarkers was analysed. Arterial inflammation was measured at seven arterial segments and normalized to venous FDG activity to produce target to background ratios (TBR). Thirty-four subjects without cardiovascular disease who repeated PET 1–4 years apart for routine health check-ups were retrospectively evaluated for comparison.

Results

The baseline mean TBR values in atherosclerotic patients were positively correlated with age (R = 0.36), body mass index (R = 0.54), abdominal visceral adipose tissue volume (R = 0.65), coronary calcification score (R = 0.40), levels of low-density lipoprotein cholesterol (R = 0.54), matrix metalloproteinase (MMP)-9 (R = 0.46) and fatty acid binding protein 4 (FABP4) (R = 0.67, all p < 0.05). The TBR as well as high-sensitivity C-reactive protein (hsCRP), E-selectin, MMP-9, monocyte chemotactic protein 1, FABP4 and follistatin values were reduced significantly after the 12-week atorvastatin treatment. The TBR reduction marginally correlated with changes in MMP-9 levels (R = 0.56, p = 0.05). The control group, whose median age was younger, by comparison had lower hsCRP and arterial TBR than the subjects with atherosclerosis (all p < 0.05), and moreover had a slight but insignificant increase in mean TBR at their 2.5±0.8 year follow-up.

Conclusion

The medium dose of atorvastatin over a 12-week period resulted in a significant reduction of arterial inflammation as well as various circulating biomarkers.

Keywords

18F-Fluorodeoxyglucose positron emission tomography Inflammation Calcification Biomarker Statin 

Notes

Acknowledgements

This study was supported in part by grant NSC 96-2321-B-002-029-MY2, NSC 98-2314-B-002-145-MY2 from the National Science Council of Taiwan and Pfizer Limited (Taiwan). The authors acknowledge the assistance provided by the National Taiwan University Hospital, Center for PET and Health Management Center staff.

Conflicts of interest

This study is in part supported by Pfizer Limited (Taiwan).

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Yen-Wen Wu
    • 1
    • 2
  • Hsian-Li Kao
    • 1
  • Chi-Lun Huang
    • 3
  • Ming-Fong Chen
    • 1
  • Lian-Yu Lin
    • 1
  • Yi-Chih Wang
    • 1
  • Yen-Hung Lin
    • 1
  • Hung-Ju Lin
    • 1
  • Kai-Yuan Tzen
    • 2
  • Ruoh-Fang Yen
    • 2
  • Yu-Chiao Chi
    • 4
  • Por-Jau Huang
    • 1
  • Wei-Shiung Yang
    • 1
    • 4
  1. 1.Department of Internal MedicineNational Taiwan University HospitalTaipeiTaiwan
  2. 2.Department of Nuclear MedicineNational Taiwan University HospitalTaipeiTaiwan
  3. 3.Department of Internal MedicineTao-Yuan General HospitalTao-YuanTaiwan
  4. 4.Graduate Institute of Clinical Medicine, College of MedicineNational Taiwan UniversityTaipeiTaiwan

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