Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography

  • Michael Fiechter
  • Jelena R. Ghadri
  • Silke M. Kuest
  • Aju P. Pazhenkottil
  • Mathias Wolfrum
  • Rene N. Nkoulou
  • Robert Goetti
  • Oliver Gaemperli
  • Philipp A. Kaufmann
Original Article

Abstract

Purpose

We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.

Methods

The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day 99mTc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥50% luminal narrowing) was calculated on a per-patient basis.

Results

The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.

Conclusion

In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.

Keywords

CZT SPECT MPI Invasive coronary angiography Accuracy Attenuation correction 

Notes

Acknowledgments

Financial contributions from the Swiss National Science Foundation (323630-128868/1 to M.F. and 320030-127604/1 to P.A.K.) are gratefully acknowledged. Furthermore, we thank Daisy Beutel, Serpil Bostanci-Kökylidirim, Mirjam De Bloeme, Edlira Loga, Ennio Mueller and Patrick von Schulthess for their technical support.

Conflicts of interest

The University Hospital Zurich holds a research contract with GE Healthcare.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Michael Fiechter
    • 1
    • 2
  • Jelena R. Ghadri
    • 1
  • Silke M. Kuest
    • 1
  • Aju P. Pazhenkottil
    • 1
  • Mathias Wolfrum
    • 1
  • Rene N. Nkoulou
    • 1
  • Robert Goetti
    • 1
  • Oliver Gaemperli
    • 1
  • Philipp A. Kaufmann
    • 1
    • 2
  1. 1.Department of Radiology, Cardiac ImagingUniversity Hospital ZurichZurichSwitzerland
  2. 2.Zurich Center for Integrative Human Physiology (ZIHP)University of ZurichZurichSwitzerland

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