Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography
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We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.
The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day 99mTc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥50% luminal narrowing) was calculated on a per-patient basis.
The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.
In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.
KeywordsCZT SPECT MPI Invasive coronary angiography Accuracy Attenuation correction
Financial contributions from the Swiss National Science Foundation (323630-128868/1 to M.F. and 320030-127604/1 to P.A.K.) are gratefully acknowledged. Furthermore, we thank Daisy Beutel, Serpil Bostanci-Kökylidirim, Mirjam De Bloeme, Edlira Loga, Ennio Mueller and Patrick von Schulthess for their technical support.
Conflicts of interest
The University Hospital Zurich holds a research contract with GE Healthcare.
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