Evolving role of FDG PET imaging in assessing joint disorders: a systematic review

  • Kathleen Carey
  • Babak Saboury
  • Sandip Basu
  • Alex Brothers
  • Alexis Ogdie
  • Tom Werner
  • Drew A. Torigian
  • Abass Alavi
Review Article

Abstract

Assessing joint disorders has been a relatively recent and evolving application of 18F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) imaging. FDG is taken up by inflammatory cells, particularly when they are active as part of an ongoing inflammatory process. Hence FDG PET has been employed to assess a wide array of arthritic disorders. FDG PET imaging has been investigated in various joint diseases for diagnostic purposes, treatment monitoring, and as a prognostic indicator as in other disorders. In some of the diseases the ancillary findings in FDG PET have provided important clues about the underlying pathophysiology and pathogenesis processes. While substantial promise has been demonstrated in a number of studies, it is clear that the potential utility of PET in this clinical realm far outweighs that which has been established to date.

Keywords

18F-Fluorodeoxyglucose Positron emission tomography Arthritis Osteoarthritis Inflammation 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Kathleen Carey
    • 1
  • Babak Saboury
    • 1
  • Sandip Basu
    • 1
  • Alex Brothers
    • 1
  • Alexis Ogdie
    • 1
  • Tom Werner
    • 1
  • Drew A. Torigian
    • 1
  • Abass Alavi
    • 1
    • 2
  1. 1.Department of Radiology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of RadiologyHospital of the University of PennsylvaniaPhiladelphiaUSA

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