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18F-FDG PET/CT in paediatric lymphoma: comparison with conventional imaging

  • Kevin London
  • Siobhan Cross
  • Ella Onikul
  • Luciano Dalla-Pozza
  • Robert Howman-Giles
Original Article

Abstract

Purpose

In children with Hodgkin’s disease and non-Hodgkin’s lymphoma, the ability of 18F-fluoro-2-deoxy-D-glucose PET/CT and conventional imaging (CI) to detect malignant lesions and predict poor lesion response to therapy was assessed and compared.

Methods

A retrospective review of findings reported on PET/CT and CI was performed using a lesion-based analysis of 16 lymph node and 8 extra-nodal regions. Lesions were defined by histopathological findings or follow-up > 6 months.

Results

The study included 209 PET/CT scans with a valid CI comparator. A total of 5,014 regions (3,342 lymph node, 1,672 extra-nodal) were analysed. PET/CT performed significantly better than CI in the detection of malignant lesions with sensitivity and specificity of 95.9 and 99.7% compared to 70.1 and 99.0%, respectively. For predicting poor lesion response to therapy, PET/CT had fewer false-positive lesions than CI. The specificity for predicting poor lesion response to treatment for PET/CT was 99.2% compared to 96.9% for CI. PET/CT was the correct modality in 86% of lesions with discordant findings.

Conclusion

PET/CT is more accurate than CI in detecting malignant lesions in childhood lymphoma and in predicting poor lesion response to treatment. In lesions with discordant findings, PET/CT results are more likely to be correct.

Keywords

Paediatric lymphoma Sensitivity Specificity FDG PET/CT 

Notes

Acknowledgements

Kevin London was gratefully supported by The Cancer and Research Support Fund, Oncology Unit, The Children’s’ Hospital at Westmead, Sydney, Australia.

Conflicts of interest

None.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Kevin London
    • 1
  • Siobhan Cross
    • 2
  • Ella Onikul
    • 3
  • Luciano Dalla-Pozza
    • 2
  • Robert Howman-Giles
    • 1
    • 4
  1. 1.Department of Nuclear MedicineThe Children’s Hospital at WestmeadSydneyAustralia
  2. 2.Oncology UnitThe Children’s Hospital at WestmeadSydneyAustralia
  3. 3.Department of Medical ImagingThe Children’s Hospital at WestmeadSydneyAustralia
  4. 4.Discipline of Imaging, Sydney Medical SchoolUniversity of SydneySydneyAustralia

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