FDG PET/CT for monitoring response to neoadjuvant chemotherapy in breast cancer patients

  • Katharina Dalus
  • Gundula Rendl
  • Lukas Rettenbacher
  • Christian Pirich
Letter to the Editor

Dear Sir,

The recently published study of Straver et al. describes the potential value of FDG PET/CT for monitoring neoadjuvant chemotherapy in a selective population of breast cancer patients.

Several annotations referring to both methodological and clinical aspects need to be made.

Straver et al. claim that a sufficiently prominent visualization of axillary lymph node metastases with FDG PET/CT allows monitoring of the axillary response. Several problems occurred in previous studies investigating the value of FDG PET(/CT) for monitoring response to neoadjuvant chemotherapy in breast cancer patients [1, 2, 3, 4]:

First, various criteria to define tumour response in breast cancer patients have been proposed: response can be assessed clinically and/or pathohistologically. Among the definitions of clinical response, the criteria validated by the Response Evaluation Criteria in Solid Tumours (RECIST) Group in the year 2000 is widely accepted and has been frequently used [5]. For...


Breast Cancer Patient Axillary Lymph Node Standardize Uptake Value Axillary Lymph Node Metastasis Positive Axillary Lymph Node 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Katharina Dalus
    • 1
  • Gundula Rendl
    • 1
  • Lukas Rettenbacher
    • 1
  • Christian Pirich
    • 1
  1. 1.Department of Nuclear Medicine and EndocrinologyParacelsus Private Medical University SalzburgSalzburgAustria

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