Feasibility of 90Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres
90Y-labelled compounds used in targeted radiotherapy are usually imaged with SPECT by recording the bremsstrahlung X-rays of the β decay. The continuous shape of the X-ray spectrum induces the presence of a significant fraction of scatter rays in the acquisition energy window, reducing the accuracy of biodistribution and of dosimetry assessments.
The aim of this paper is to use instead the low branch of e− e+ pair production in the 90Y decay. After administration of 90Y-labelled SIR-Spheres by catheterization of both liver lobes, the activity distribution is obtained by 90Y time-of-flight (TOF) PET imaging. The activity distribution is convolved with a dose irradiation kernel in order to derive the regional dosimetry distribution.
Evaluation on an anatomical phantom showed that the method provided an accurate dosimetry assessment. Preliminary results on a patient demonstrated a high-resolution absorbed dose distribution with a clear correlation with tumour response.
This supports the implementation of 90Y PET in selective internal radiation therapy of the liver.
Keywords90Y PET imaging SIRT Dosimetry Microspheres
The authors thank Glenn Flux, Ph.D., for helpful comments.
Conflicts of interest
- 19.de Jong M, Bakker WH, Krenning EP, Breeman WAP, van der Pluijm ME, Bernard BF, et al. Yttrium-90 and indium-111 labelling, receptor binding and biodistribution of [DOTA0,d-Phe1, Tyr3]octreotide, a promising somatostatin analogue for radionuclide therapy. Eur J Nucl Med 1997;24:368–71.CrossRefPubMedGoogle Scholar
- 30.Campbell JM, Wong CO, Muzik O, Marples B, Joiner M, Burmeister J. Early dose response to yttrium-90 microsphere treatment of metastatic liver cancer by a patient-specific method using single photon emission computed tomography and positron emission tomography. Int J Radiat Oncol Biol Phys 2009;74(1):313–20.PubMedGoogle Scholar
- 31.Bilbao JI, Reiser MF, editors. Liver radioembolization with 90Y microspheres (medical radiology/diagnostic imaging). Berlin: Springer; 2008. p. 86.Google Scholar
- 33.Wang W, Hu Z, Gualtieri EE, Parma MJ, Walsh ES, Sebok D, et al. Systematic and distributed time-of-flight list mode PET reconstruction. IEEE Nucl Sci Symp Conf Rec 2006;3:1715–22.Google Scholar
- 35.Cross WG, Freedman NO, Wong PY. Tables of beta-ray dose distributions in water. Ontario: Atomic Energy of Canada, Ltd, Report No AECL-10521; 1992. http://inisdb2.iaea.org/inis/php/download.php?s=p&rn=23047981.
- 38.Vardi Y, Lee D. From image deblurring to optimal investments: maximum likelihood solutions for positive linear inverse problems. J R Stat Soc Series B Stat Methodol 1993;55(3):569–612.Google Scholar
- 39.Phelps ME, editor. PET: physics, instrumentation, and scanners. New York: Springer; 2006.Google Scholar
- 41.Kennedy A, Nag S, Salem R, Murthy R, McEwan AJ, Nutting C, et al. Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium. Int J Radiat Oncol Biol Phys 2007;68(1):13–23.PubMedGoogle Scholar
- 42.US Nuclear Regulatory Commission. 2007–10: yttrium-90 theraspheres and sirspheres impurities. Washington, DC: US Nuclear Regulatory Commission; 2007. NRC Information Notice.Google Scholar
- 45.Moszynski M. NATO security through science series: radiation detectors for medical applications. Dordrecht: Springer; 2006. p. 293–315.Google Scholar