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EANM Dosimetry Committee guidelines for bone marrow and whole-body dosimetry

  • Cecilia HindorfEmail author
  • Gerhard Glatting
  • Carlo Chiesa
  • Ola Lindén
  • Glenn Flux
Guidelines

Abstract

Introduction

The level of administered activity in radionuclide therapy is often limited by haematological toxicity resulting from the absorbed dose delivered to the bone marrow. The purpose of these EANM guidelines is to provide advice to scientists and clinicians on data acquisition and data analysis related to bone-marrow and whole-body dosimetry.

Materials and methods

The guidelines are divided into sections “Data acquisition” and “Data analysis”. The Data acquisition section provides advice on the measurements required for accurate dosimetry including blood samples, quantitative imaging and/or whole-body measurements with a single probe. Issues specific to given radiopharmaceuticals are considered. The Data analysis section provides advice on the calculation of absorbed doses to the whole body and the bone marrow. The total absorbed dose to the bone marrow consists of contributions from activity in the bone marrow itself (self-absorbed dose) and the cross-absorbed dose to the bone marrow from activity in bone, larger organs and the remainder of the body.

Conclusion

As radionuclide therapy enters an era where patient-specific dosimetry is used to guide treatments, accurate bone-marrow and whole-body dosimetry will become an essential element of treatment planning. We hope that these guidelines will provide a basis for the optimization and standardization of the treatment of cancer with radiopharmaceuticals, which will facilitate single- and multi-centre radionuclide therapy studies.

Keywords

Internal dosimetry Radionuclide therapy Bone marrow 

Notes

Acknowledgments

This work was developed under the close supervision of the Dosimetry Committee of the EANM (M. Bardiès, C. Chiesa, G. Flux, M. Konijnenberg, M. Lassmann, M. Monsieurs, S.-E. Strand). In addition, the authors wish to acknowledge the contribution from S. Savolainen, past member of the EANM Dosimetry Committee.

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Copyright information

© EANM 2010

Authors and Affiliations

  • Cecilia Hindorf
    • 1
    Email author
  • Gerhard Glatting
    • 2
  • Carlo Chiesa
    • 3
  • Ola Lindén
    • 4
  • Glenn Flux
    • 5
  1. 1.Imagerie MédicaleONIRIS - Ecole Nationale Vétérinaire, Agroalimentaire et d’Alimentation Nantes AtlantiqueNantesFrance
  2. 2.Klinik für NuklearmedizinUniversität UlmUlmGermany
  3. 3.Nuclear Medicine DivisionFoundation IRCCS Istituto Nazionale TumoriMilanoItaly
  4. 4.Department of OncologyLund University HospitalLundSweden
  5. 5.Joint Department of PhysicsRoyal Marsden Hospital & Institute of Cancer ResearchLondonUK

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