Clinical features and 123I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson’s disease

  • Francisco J. Diaz-Corrales
  • Salome Sanz-Viedma
  • David Garcia-Solis
  • Teresa Escobar-Delgado
  • Pablo Mir
Original Article

Abstract

Purpose

To determine clinical predictors and accuracy of 123I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson’s disease (PD).

Methods

Several clinical features and 123I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (PDu) and 22 patients with PD without a previous history of antidopaminergic treatment (PDc) were retrospectively evaluated.

Results

DIP and PD shared all clinical features except symmetry of parkinsonian signs which was more frequently observed in patients with DIP (46.9%) than in patients with PDu (16.0%, p<0.05) or PDc (4.5%, p<0.01). Qualitatively 123I-FP-CIT SPECT images were normal in 29 patients with DIP (90.6%) and abnormal in all patients with PD, and this imaging technique showed high levels of accuracy.

Conclusion

DIP and PD are difficult to differentiate based on clinical signs. The precision of clinical diagnosis could be reliably enhanced by 123I-FP-CIT SPECT imaging.

Keywords

Drug-induced parkinsonism Parkinson’s disease 123I-FP-CIT SPECT imaging Dopamine transporter 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Francisco J. Diaz-Corrales
    • 1
  • Salome Sanz-Viedma
    • 2
  • David Garcia-Solis
    • 2
    • 3
  • Teresa Escobar-Delgado
    • 1
  • Pablo Mir
    • 1
    • 3
    • 4
  1. 1.Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de SevillaHospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevilleSpain
  2. 2.Unidad Diagnóstica de Medicina NuclearHospital Universitario Virgen del RocioSevilleSpain
  3. 3.Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)SevilleSpain
  4. 4.Unidad de Trastornos del Movimiento. Servicio de NeurologíaHospital Universitario Virgen del RocíoSevilleSpain

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