Clinical features and 123I-FP-CIT SPECT imaging in drug-induced parkinsonism and Parkinson’s disease
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To determine clinical predictors and accuracy of 123I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson’s disease (PD).
Several clinical features and 123I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (PDu) and 22 patients with PD without a previous history of antidopaminergic treatment (PDc) were retrospectively evaluated.
DIP and PD shared all clinical features except symmetry of parkinsonian signs which was more frequently observed in patients with DIP (46.9%) than in patients with PDu (16.0%, p<0.05) or PDc (4.5%, p<0.01). Qualitatively 123I-FP-CIT SPECT images were normal in 29 patients with DIP (90.6%) and abnormal in all patients with PD, and this imaging technique showed high levels of accuracy.
DIP and PD are difficult to differentiate based on clinical signs. The precision of clinical diagnosis could be reliably enhanced by 123I-FP-CIT SPECT imaging.
KeywordsDrug-induced parkinsonism Parkinson’s disease 123I-FP-CIT SPECT imaging Dopamine transporter
This study was supported by grants from the Ministerio de Educación y Ciencia de España (SAF2007-60700), the Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucia (CVI-02526), and the Consejería de Salud de la Junta de Andalucia (PI-0377/2007). Francisco J. Díaz Corrales was supported by a fellowship from the Fundación Carolina/BBVA. The authors thank Javier Luis Simón and Juan Manuel Praena Fernández for their valuable statistical advice. We thank Asad Nawaz for English grammar corrections.
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