EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2

  • Koen Van LaereEmail author
  • Andrea Varrone
  • Jan Booij
  • Thierry Vander Borght
  • Flavio Nobili
  • Özlem L. Kapucu
  • Zuzana Walker
  • Kjell Någren
  • Klaus Tatsch
  • Jacques Darcourt


The guidelines summarize the current views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The aims of the guidelines are to assist nuclear medicine practitioners in making recommendations, performing, interpreting and reporting the results of clinical dopamine D2 receptor SPECT or PET studies, and to achieve a high quality standard of dopamine D2 receptor imaging, which will increase the impact of this technique in neurological practice.

The present document is an update of the first guidelines for SPECT using D2 receptor ligands labelled with 123I [1] and was guided by the views of the Society of Nuclear Medicine Brain Imaging Council [2], and the individual experience of experts in European countries. The guidelines intend to present information specifically adapted to European practice. The information provided should be taken in the context of local conditions and regulations.


Brain Dopamine D2 receptor SPECT PET Parkinsonism 



The members of the ENC acknowledge the role of the following persons (in alphabetical order) for their advice and contribution to this and the previous guidelines: S. Asenbaum, M. Bardiés, A. Bischof Delaloye, R. Boellaard, P. Bartenstein, A. Catafau, L. Friberg, C. Halldin, M. Nowak Lonsdale, L. Pilowsky, A. Pupi and M. Seppänen, as well as the EANM Dosimetry and Physics Committee.


These guidelines summarize the views of the Neuroimaging Committee of the EANM and reflect recommendations for which the EANM cannot be held responsible. The recommendations should be taken in the context of good practice of nuclear medicine and do not substitute for national and international legal or regulatory provisions. The guidelines have been brought to the attention of the National Societies of Nuclear Medicine.


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Copyright information

© EANM 2009

Authors and Affiliations

  • Koen Van Laere
    • 1
    Email author
  • Andrea Varrone
    • 2
  • Jan Booij
    • 3
  • Thierry Vander Borght
    • 4
  • Flavio Nobili
    • 5
  • Özlem L. Kapucu
    • 6
  • Zuzana Walker
    • 7
  • Kjell Någren
    • 8
  • Klaus Tatsch
    • 9
  • Jacques Darcourt
    • 10
  1. 1.Division of Nuclear MedicineUniversity Hospital LeuvenLeuvenBelgium
  2. 2.Department of Clinical Neuroscience, Psychiatry SectionKarolinska InstituteStockholmSweden
  3. 3.Department of Nuclear Medicine, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  4. 4.Nuclear Medicine DivisionUniversité Catholique de Louvain, Mont-Godinne Medical CenterYvoirBelgium
  5. 5.Clinical Neurophysiology Unit, San Martino HospitalUniversity of GenoaGenovaItaly
  6. 6.Department of Nuclear MedicineGazi UniversityAnkaraTurkey
  7. 7.Psychiatry, Department of Mental Health SciencesUniversity College LondonLondonUK
  8. 8.RigshospitaletCopenhagen University HospitalCopenhagenDenmark
  9. 9.Department of Nuclear MedicineMunicipal Hospital of Karlsruhe IncKarlsruheGermany
  10. 10.Nuclear Medicine DivisionCentre Antoine Lacassagne and University Hospital, Université de Nice Sophia AntipolisNiceFrance

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