Evaluation of left ventricular volumes and ejection fraction by gated SPECT and cardiac MRI in patients with dilated cardiomyopathy

  • Feng Wang
  • Jian Zhang
  • Wei Fang
  • Shi-Hua Zhao
  • Min-Jie Lu
  • Zuo-Xiang HeEmail author
Original Article



The goal of this study was to evaluate the accuracy of gated single photon emission computed tomography (SPECT) in the assessment of left ventricular (LV) end-diastolic/end-systolic volumes (EDV, ESV) and ejection fraction (LVEF) in patients with dilated cardiomyopathy, using cardiac magnetic resonance imaging (MRI) as the reference method. Furthermore, software-specific characteristics of Quantitative Gated SPECT (QGS), Emory Cardiac Toolbox (ECTB) and 4D-MSPECT were analysed.


Thirty-six patients with dilated cardiomyopathy who underwent gated 99mTc-methoxyisobutylisonitrile SPECT and cardiac MRI were included. LV EDV, ESV and LVEF values of gated SPECT were calculated using QGS, ECTB and 4D-MSPECT.


The correlation between the results of gated SPECT and cardiac MRI was excellent for EDV [R = 0.872 (QGS), R = 0.879 (ECTB), R = 0.869 (4D-MSPECT)], ESV [R = 0.908 (QGS), R = 0.897 (ECTB), R = 0.880 (4D-MSPECT)] and LVEF [R = 0.794 (QGS), R = 0.763 (ECTB), R = 0.710 (4D-MSPECT)]. EDV and ESV assessed by QGS did not differ significantly from those assessed by cardiac MRI (all p = NS), whereas EDV and ESV were overestimated by ECTB and 4D-MSPECT compared with cardiac MRI (all p < 0.05). LVEF was overestimated by QGS, ECTB and 4D-MSPECT compared with cardiac MRI (all p < 0.05).


The correlation between gated SPECT and cardiac MRI is excellent for LV volume and LVEF values calculated by QGS, ECTB and 4D-MSPECT in patients with dilated cardiomyopathy. However, algorithm-varying over- or underestimation of LV volumes and LVEF should be accounted for in the clinical context.


Dilated cardiomyopathy Gated SPECT Cardiac MRI Left ventricular volumes Ejection fraction 



This study is supported by the National Science & Technology Pillar Program in the Eleventh Five-year Plan Period, People’s Republic of China (2007BAI05B01).


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Feng Wang
    • 1
  • Jian Zhang
    • 2
  • Wei Fang
    • 1
  • Shi-Hua Zhao
    • 3
  • Min-Jie Lu
    • 3
  • Zuo-Xiang He
    • 1
    Email author
  1. 1.Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingPeople’s Republic of China
  2. 2.Heart Failure Care Unit, Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingPeople’s Republic of China
  3. 3.Department of Radiology, Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingPeople’s Republic of China

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